Bavarian Nordic said it had been selected by the Defense Threat Reduction Agency - which is part of the US Department of Defense - for the development of a vaccine against Burkholderia pseudomallei and Burkholderia mallei
which are seen as potential threats to national security.
We examined ten Burkholderia mallei
, ten Burkholderia pseudomallei, and 40 other bacterial strains, including 15 B.
is the agent responsible for "glanders," a disease generally affecting livestock.
is the etiologic agent of glanders, a disease primarily of equids, which is also communicable to man with fatal consequences.
Antibiotic susceptibility of 65 isolates of Burkholderia pseudomallei and Burkholderia mallei
to 35 antimicrobial agents.
The role of capsule formation in Burkholderia mallei
for its persistence in vivo.
The five pathogens studied were Bacillus anthracis, Yersinia pestis, Francisella tularensis, Burkholderia pseudomallei and Burkholderia mallei
, the etiologic agent of glanders, is thought to have evolved from a single strain of B.
anthracis, Burkholderia mallei
, and Burkholderia pseudomallei strains were received from either the CDC or the NIH Biodefense and Emerging Infections Research Resources Repository (BEI Resources, Bethesda, MD, USA).
Glanders is a highly-contagious bacterial illness caused by the bacterium burkholderia mallei
that occurs primarily in horses and has no known vaccination or cure.
Glanders is not airborne, it's an infectious disease caused by the bacterium Burkholderia mallei
, usually by ingestion of contaminated food or water.
Phenol-chloroform extraction of DNA from standard strains of Bacillus anthracis Vollum and Sterne, Yersinia pestis 0092, and Burkholderia mallei
(ATCC 23344) was performed as described previously (13) in a biosafety level III laboratory certified to work with select agents (registration number 20011016-798; entity number 020031123-0125).