Hagemann et al., "Tumour hypoxia promotes tolerance and angiogenesis via CCL28
and T(reg) cells," Nature, vol.
Our laboratory evaluated the use of CCL27 and CCL28 to augment responses to an influenza hemagglutinin- (HA-) encoding DNA vaccine .
CCL25, CCL27, and CCL28 are some of the most well-studied mucosal chemokines and are used to promote the generation of antigen-specific mucosal immunity following immunization.
In an attempt to replicate the Iwaski "prime and pull" method of classical protein immunization and topical application of chemokine in the context of an HIV-1 vaccine, Tregoning and colleagues vaccinated animals with trimeric HIV-1 gp140 and applied CCL28 to the vaginal surface six days after each immunization.
Por otro lado, se ha mostrado en humanos y en ratones que el CCL28 tiene una potente actividad antimicrobiana frente a C.
CCL28 has dual roles in mucosal immunity as a chemokine with broad-spectrum antimicrobial activity.
CCL28 has dual roles in mucosal immunity as a chemokine with broadspectrum antimicrobial activity.
Since IL1a was clearly not identified as the soluble mediator, similar experiments were performed with antibodies against other proinflammatory cytokines TNF-[alpha], CCL27, CCL28
, and IL-18 (data not shown).
Noteworthy, recently a role for chemokines in immune evasion was shown for CC-chemokine ligand 28 (CCL28
Group I- Group II- preterm labor false preterm labor n = 62 n = 47 Chemokines concentration (pg/mL) Median (min-max) 6Ckine 11539 (2713-77761) 12543 (3226-39407) Axl 1306 (529.5-7509) 1389 (601.4-3074) BTC 8924 (5577-32195) 8246 (5383-18495) CCL28
13504 (7193-41772) 13959 (7923-78508) CTACK/CCL27 3831 (1028-93251) 4138 (1006-25364) CXCL16 2849 (1789-7924) 2844 (1260-13175) ENA-78/CXCL5 2894 (380.8-16116) 2728 (799.4-19843) Eotaxin-3 4545 (2229-18529) 4269 (1507-23502) GCP-2 709.7 (132.1-2507) 743.8 (190-1841) GRO [alpha].
cHL cells secrete cytokines/chemokines and express a variety of cytokine/chemokine receptors [8,47] and it is now widely assumed that the clinical and histological features of cHL are primarily due to the effects of a plethora of cytokines and chemokines secreted by cHL cells such as CCL5 [48, 49], CCL17 , CCL22 , CCL28 , and CCL20 [39, 52] or by the surrounding cellular infiltrate.
Miyazato et al., "Expression of CCL28 by Reed-Sternberg cells defines a major subtype of classical Hodgkin's disease with frequent infiltration of eosinophils and/or plasma cells," American Journal of Pathology, vol.