Additional candidates have been highlighted in the literature, including the leukotoxin LukED which targets the human CCR5 receptor
LPS induces CCR5 receptor
expression via the EGFR, COX-2 and ERK1/2 pathways
The CCR5 receptor
is a major entry site for macrophage-tropic (CCR5 tropic) HIV-1 strains into host cells.
Altering CCR5 receptor
will help disable the virus' ability to use T-cells to infect humans.
One thing that we've lacked is a high-resolution molecular ' picture' of the CCR5 receptor
structure that we can use for precise drug design," Beili Wu, professor at the Chinese Academy of Shanghai Institute of Materia Medica, part of the Chinese Academy of Sciences, said in a statement.
Mitsuyasu and Cannon, discussed their ongoing, extraordinary and promising efforts in the area of anti-HIV gene and stem cell therapy to knock out the CCR5 receptor
or "hook" onto which the HIV virus latches in order to enter the T-cell.
have developed a technique using a protein that recognizes and binds to the CCR5 receptor
gene, genetically modifying it to mimic the naturally resistant version.
Today the mutation can be found in [approximately equal to]10% of all those of northern European descent, preventing expression of the as-yet mostly inscrutable CCR5 receptor
on the surface of many different subsets of immune cells.
The patent is entitled Ribozymes Capable of Inhibiting the Expression of the CCR5 Receptor
This new class of HIV drugs blocks HIV from attaching onto the CCR5 receptor
on the T-cell, making it hard for the virus to enter T cells.
Other HGS drugs in clinical development include two TRAIL receptor antibodies for the treatment of hematologic and solid malignancies, in addition to an antibody to the CCR5 receptor
for the treatment of HIV/AIDS.
Notably, genetic analysis has shown that these individuals tend to have polymorphisms within the CCR gene promotor region that are associated with low expression of the CCR5 receptor
, which is used by HIV to enter the cell.