CD4


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CD4

(immunology)
A T-cell signaling and/or co-stimulatory monomeric transmembrane glycoprotein involved in major histocompatibility complex II adhesion.
References in periodicals archive ?
CD4 testing is critical for identifying the patients for whom these extra efforts are needed, and will remain an important tool in HIV treatment and care for many years.
Restoration of the CD4 T cell compartment after long-term highly active antiretroviral therapy without phenotypical signs of accelerated immunological aging.
Idiopathic CD4 lymphocytopenia for the first time was described in the year 1992 by the CDC, as cases which demonstrated depressed (<300/cumm) numbers and proportions of CD4 count (<20% of total T cells), on at least two consecutive occasions, with no laboratory evidence of HIV-1 and HIV-2 infection, HTLV-1 or HTLV-2 infection, and the absence of any primary or secondary immunodeficiency disease, or treatment associated with depressed level of CD4 levels.
This analysis figured mortality by gender, age, latest CD4 count (under 200, 200 to 349, or over 349), and viral load (below or above 400 copies).
Quantitative real time PCR (qPCR) was applied to analyze the expression level of the porcine CD4 gene using a LightCycler[R] 480 II instrument (Roche Diagnostics GmbH, Germany).
The cytomegalovirus-specific CD4 T-cell response expands with age and markedly alters the CD4 T-cell repertoire.
Ensuring accurate CD4 counts has become more important recently, since ART is being initiated at higher CD4 counts, when clinical signs tend to be less sensitive in detecting immune suppression.
A study in South Africa found that among those eligible for treatment, receipt of a CD4 count at the time of HIV diagnosis doubled retention in care when compared with returning for a CD4 test result one week later.
A study conducted in 20 healthy HIV-negative individuals showed significant decrease in the CD4 lymphocyte count after the rest for 60 min.