cytotoxic T cell

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Related to CD8+ T cells: lymphocyte activation

cytotoxic T cell

[¦sīd·ə‚täk·sik ′tē ‚sel]
(immunology)
A type of T cell which protects against pathogens that invade host cell cytoplasm, where they cannot be bound by antibodies, by recognizing and killing the host cell before the pathogens can proliferate and escape.
References in periodicals archive ?
Patients who responded to combination therapy had increased CD8+ T cells, elevated PD-L1 protein expression, [and] IFN-gamma gene expression on several cell subsets in tumors after [T-vec] treatment.
Due to its enhanced half-life, AM0010 has strong immune-stimulating effects that induce the activation, proliferation, and survival of intra-tumoral, tumor-reactive, cytotoxic CD8+ T cells in patients.
The mTOR kinase determines effector versus memory CD8+ T cell fate by regulating the expression of transcription factors T-bet and eomesodermin.
Compared with normal chow diet-fed mice, the high-fat diet mice showed worsened blood sugar, increased triglycerides, a type of fat (lipid) in the blood, and a substantial increase in the numbers of CD8+ T cells in the liver.
Females have lower levels of CD8+ T cells and higher CD4/CD8 ratios than males, due to the effects of estrogen.
The CD4+ T cells count and percentage; CD8+ T cell count and CD4+ T cells/ CD8+ T cells ratio improvement after the commencement of the treatment are shown in table 1 and figure 2: A-D.
Molecules like CD160, 2B4, Programmed Death-1 (PD-1), and Cytotoxic T- lymphocyte Antigen 4 (CTLA-4), have been identified as inductors of negative signals, which regulates the activation events of CD4+ and CD8+ T cells (1).
Cantor and colleagues discovered that a small, but critically important, population of CD8+ T cells (less than 5 percent), plays a specialized role in protecting from lupus.
The distribution of CD38 expression on CD8+ T cells is continuous and does not show clearly defined negative or positive populations in either healthy or HIV-1-infected individuals, nor does it follow a Gaussian distribution when defined by isotype controls [78].
Cinnamon extract suppresses tumor progression by modulating angiogenesis and the effector function of CD8+ T cells.
After the inhalation of droplets containing the bacilli, alveolar macrophages and CD4+ and CD8+ T cells interact to form a granuloma at the site of infection, which consists primarily of macrophages and lymphocytes surrounding a central area of necrosis.