CD38 expression on cryopreserved CD8+ T cells
predicts HIV disease progression.
Depletion of CD8+ T cells
reduces the capacity of primed mice to respond to influenza infection, which indicates a role for CD8+ T cells
in the protective secondary response.
New knowledge about the way the cells function might lead to vaccines which avoid the development of poorly functioning CD8+ T cells
These lower limits of detection corresponded to as few as of 230 CD4+ or 125 CD8+ T cells
in the assay wells.
One reason this may occur is due to the presence of CD8+ T cells
with particular functional characteristics.
Using the markers CD38 and HLA-DR on CD8+ T cells
they showed that, in patients with a good response to ART (undetectable viral load at 6 and 12 months), there was a rapid fall in activation during the first 6 months of treatment.
Absolute CD4+ and CD8+ T cell
counts are measurements used to monitor disease progression in HIV/AIDS patients, to determine when to begin treatment with antiretroviral drugs and to monitor a patient's response to treatment.
The published paper notes the findings of other research that, to be effective, a cancer vaccine should produce both CD8+ T cells
(such as CTLs) that bind to antigenic peptides in association with MHC Class I molecules, and CD4+ "helper" T cells that bind to antigens in the context of MHC Class II molecules.
Washington, May 18 (ANI): Researchers at Duke University Medical School and Mount Sinai School of Medicine have discovered a new role for a host protein that provides further insight into how CD8+ T cells
work to control HIV and other infections.
Removal of CD8+ T Cells
From Donor Stem Cell Transplants --
In preclinical studies using the Eligix Separation System, high levels of CD8+ T cells
were selectively depleted, while the immune cells and stem cells that are necessary to repopulate into the different blood cells, which the body needs, were preserved.
Perforin expression is characteristic of activated CD8+ T cells
that can directly kill HIV-infected cells.