cytotoxic T cell

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Related to CD8 T cell: CD4 T cells, Memory T cells

cytotoxic T cell

[¦sīd·ə‚täk·sik ′tē ‚sel]
(immunology)
A type of T cell which protects against pathogens that invade host cell cytoplasm, where they cannot be bound by antibodies, by recognizing and killing the host cell before the pathogens can proliferate and escape.
References in periodicals archive ?
Caption: Figure 1: The effect of glutaraldehyde fixation of Fly/[L.sup.d]/B7.1/ICAM cells on CD8 T cell activation, proliferation, and CTL function.
IL-10 is required for optimal CD8 T cell memory following Listeria monocytogenes infection.
Antigen-independent memory CD8 T cells do not develop during chronic viral infection.
This study reports T cell activation defined by CD38 and HLA-DR with quantitative assessment of CD38 and compares these measures of immune activation with serological markers, and uses proportional hazards modelling to demonstrate that CD8 T cell activation defined by CD38 expression was the strongest predictor of clinical progression [4].
However, the reality is that most infected people make sufficient and even robust antibody and CD8 T cell responses to HIV.
CD8 T cell CD38 expression is hugely increased in HIV infection [34] and has been shown to be an important prognostic marker in patients before they start ART, independent of CD4 count and viral load [36].
A 5-mg dose that uses the CRL 1005 adjuvant consistently showed the best results, with CD8 T cell responses in particular, in rhesus monkeys immunized at 0, 4, and 8 weeks.
Jacob, "DNA methylation by DNA methyltransferase 1 is critical for effector CD8 T cell expansion," The Journal of Immunology, vol.
One theory is that HIV-infection drives up Treg, which in turn shuts down the HIV-1- specific CD8 T cell response, he said.
Scientists have induced CD8 T cell responses against malaria, but only by using DNA- or virus-based vaccines.