Caption: Figure 1: The effect of glutaraldehyde fixation of Fly/[L.sup.d]/B7.1/ICAM cells on CD8 T cell
activation, proliferation, and CTL function.
IL-10 is required for optimal CD8 T cell
memory following Listeria monocytogenes infection.
Antigen-independent memory CD8 T cells
do not develop during chronic viral infection.
This study reports T cell activation defined by CD38 and HLA-DR with quantitative assessment of CD38 and compares these measures of immune activation with serological markers, and uses proportional hazards modelling to demonstrate that CD8 T cell
activation defined by CD38 expression was the strongest predictor of clinical progression .
However, the reality is that most infected people make sufficient and even robust antibody and CD8 T cell
responses to HIV.
Hogquist, "Alternative memory in the CD8 T cell
lineage," Trends in Immunology, vol.
CD8 T cell
CD38 expression is hugely increased in HIV infection  and has been shown to be an important prognostic marker in patients before they start ART, independent of CD4 count and viral load .
A 5-mg dose that uses the CRL 1005 adjuvant consistently showed the best results, with CD8 T cell
responses in particular, in rhesus monkeys immunized at 0, 4, and 8 weeks.
Jacob, "DNA methylation by DNA methyltransferase 1 is critical for effector CD8 T cell
expansion," The Journal of Immunology, vol.
One theory is that HIV-infection drives up Treg, which in turn shuts down the HIV-1- specific CD8 T cell
response, he said.
Preliminary research thus far suggests some cross-clade CD8 T cell
Scientists have induced CD8 T cell
responses against malaria, but only by using DNA- or virus-based vaccines.