Caption: Figure 1: The effect of glutaraldehyde fixation of Fly/[L.sup.d]/B7.1/ICAM cells on
CD8 T cell activation, proliferation, and CTL function.
IL-10 is required for optimal
CD8 T cell memory following Listeria monocytogenes infection.
Antigen-independent memory
CD8 T cells do not develop during chronic viral infection.
This study reports T cell activation defined by CD38 and HLA-DR with quantitative assessment of CD38 and compares these measures of immune activation with serological markers, and uses proportional hazards modelling to demonstrate that
CD8 T cell activation defined by CD38 expression was the strongest predictor of clinical progression [4].
However, the reality is that most infected people make sufficient and even robust antibody and
CD8 T cell responses to HIV.
Hogquist, "Alternative memory in the
CD8 T cell lineage," Trends in Immunology, vol.
CD8 T cell CD38 expression is hugely increased in HIV infection [34] and has been shown to be an important prognostic marker in patients before they start ART, independent of CD4 count and viral load [36].
A 5-mg dose that uses the CRL 1005 adjuvant consistently showed the best results, with
CD8 T cell responses in particular, in rhesus monkeys immunized at 0, 4, and 8 weeks.
Jacob, "DNA methylation by DNA methyltransferase 1 is critical for effector
CD8 T cell expansion," The Journal of Immunology, vol.
One theory is that HIV-infection drives up Treg, which in turn shuts down the HIV-1- specific
CD8 T cell response, he said.
Preliminary research thus far suggests some cross-clade
CD8 T cell responses.
Scientists have induced
CD8 T cell responses against malaria, but only by using DNA- or virus-based vaccines.
