cytotoxic T cell

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cytotoxic T cell

[¦sīd·ə‚täk·sik ′tē ‚sel]
(immunology)
A type of T cell which protects against pathogens that invade host cell cytoplasm, where they cannot be bound by antibodies, by recognizing and killing the host cell before the pathogens can proliferate and escape.
References in periodicals archive ?
Further analyses also identified blunted CD4 T-cell responses (i.e., reduced proliferation as well as IFN-[gamma] and IL-2 production by the cells) as well as decreased CD8 T-cell numbers in draining lymph nodes of alcohol-consuming mice compared with control mice (Porretta et al.
Blair et al., "Distinct mechanisms mediate naive and memory CD8 T-cell tolerance," Proceedings of the National Academy of Sciences of the United States of America, vol.
Extended co-expression of inhibitory receptors by human CD8 T-cells depending on differentiation, antigen-specificity and anatomical localization.
"Direct comparisons between virus-specific CD4 and CD8 T-cell numbers within individual vaccinees revealed dynamic and independently regulated changes in T-cell memory over time," they wrote.
However, other patients "preferentially lost" CD8 T-cell memory "while leaving the antiviral CD4 T-cell compartment intact," they noted.
We have developed a Whole Blood Capcellia CD4/CD8 assay for the determination of human CD4 and CD8 T-cell counts.
Bernard et al., "Identification of a novel natural regulatory CD8 T-cell subset and analysis of its mechanism of regulation," Blood, vol.
o Led to a sustainable (over 6 month) increase in CD8 T-cell and natural killer (NK) cell numbers, together with an improved pre-dose TH1 status, the secondary PD marker.
Finally, HA-specific CD4 and CD8 T-cell cytokine and cytotoxic responses will be determined by mass cytometry for correlates of protection.At the end of this proposal, the development of a universal Flu vaccine should be achieved.
Ahmed, "Reflections on CD8 T-cell activation and memory," Immunologic Research, vol.
Subsequent sophisticated analyses of T-cell activation and proliferation in people with HIV showed that CD4 and CD8 T-cell activations are tightly correlated, confirming that immune activation does not reflect an attempt by the immune system to replace CD4 T cells killed by HIV.