Further analyses also identified blunted CD4 T-cell responses (i.e., reduced proliferation as well as IFN-[gamma] and IL-2 production by the cells) as well as decreased CD8 T-cell
numbers in draining lymph nodes of alcohol-consuming mice compared with control mice (Porretta et al.
Blair et al., "Distinct mechanisms mediate naive and memory CD8 T-cell
tolerance," Proceedings of the National Academy of Sciences of the United States of America, vol.
Extended co-expression of inhibitory receptors by human CD8 T-cells
depending on differentiation, antigen-specificity and anatomical localization.
"Direct comparisons between virus-specific CD4 and CD8 T-cell
numbers within individual vaccinees revealed dynamic and independently regulated changes in T-cell memory over time," they wrote.
However, other patients "preferentially lost" CD8 T-cell
memory "while leaving the antiviral CD4 T-cell compartment intact," they noted.
We have developed a Whole Blood Capcellia CD4/CD8 assay for the determination of human CD4 and CD8 T-cell
Bernard et al., "Identification of a novel natural regulatory CD8 T-cell
subset and analysis of its mechanism of regulation," Blood, vol.
o Led to a sustainable (over 6 month) increase in CD8 T-cell
and natural killer (NK) cell numbers, together with an improved pre-dose TH1 status, the secondary PD marker.
Functions of CD8 T-cell
subsets secreting different cytokine patterns.
Finally, HA-specific CD4 and CD8 T-cell
cytokine and cytotoxic responses will be determined by mass cytometry for correlates of protection.At the end of this proposal, the development of a universal Flu vaccine should be achieved.
Ahmed, "Reflections on CD8 T-cell
activation and memory," Immunologic Research, vol.
Subsequent sophisticated analyses of T-cell activation and proliferation in people with HIV showed that CD4 and CD8 T-cell
activations are tightly correlated, confirming that immune activation does not reflect an attempt by the immune system to replace CD4 T cells killed by HIV.