ecad

(redirected from CDH1)
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Related to CDH1: Cadherin 1

ecad

[′ē‚kad]
(ecology)
A type of plant which is altered by its habitat and possesses nonheritable characteristics.
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References in periodicals archive ?
A faulty CDH1 gene, like the BRCA mutations linked to a higher risk of breast cancer, ups the danger of developing stomach cancer.
Due to RNA availability, the samples of 20 patients were analyzed for CDH1 gene expression.
Mutations in the CDH1 gene are almost entirely somatic and result from premature truncation of the translation, frequently accompanied by loss of the wild-type allele.
We used methylated DNA probes to capture methylated targets, which were oligonucleotides from the promoter regions of cancer-related genes (cadherin 1 [ CDH1 ], and retinoic acid receptor beta [ RARB ]) as a detection model.
Aun mas, con la implementacion de paneles multigen, se sabe que muchos casos de cancer de mama hereditario presentan mutaciones en otros genes ademas del BRCA1 y BRCA2; por tanto para mejorar la sensibilidad del diagnostico genetico se sugieren plataformas de secuenciacion de muchos genes que incluyen los genes de alta penetrancia, como lo es la secuenciacion de nueva generacion o NGS (Next Generation Sequencing), en esta se incluyen genes como: ATM, BARD1, BRIP1, CDH1, CHEK2, MRE11A, MSH6, NBN, PALB2, PTEN, RAD51, RAD51C, STK11 TP53, los cuales son hoy en dia el siguiente estandar en el estudio de HBOC (23).
En este mismo estudio se identificaron en los individuos con SIIPI dos genes localizados en la region del TLR9 (que codifica proteinas que reconocen antigenos bacterianos), un gen en la region CDH1 (que codifica proteinas responsables de mantener las uniones estrechas intercelulares) y un gen mas para IL-6.
They found that a particular genetic variant in the gene called CDH1 (encoding E-cadherin) was strongly linked to survival.
Sin embargo, alteraciones en el complejo de adhesion celula-celula por mutaciones en el gen CDH1, gen que codifica la proteina E-cadherina, han sido descritas para diferentes tipos de tumores, como carcinoma lobular de mama, cancer gastrico de tipo difuso y carcinoma hepatocelular (36-38).
These were subsequently subjected to dualplex RT-qPCR analysis targeting CDH1 [cadherin 1, type 1, E-cadherin (epithelial)]/ CTNNB [catenin (cadherin-associated protein), [beta]1, 88 kDa] and CDH1/MAX (MYC associated factor X).
It screens for mutations in the BRCA1 and BRCA2 genes as well as in five additional genes, namely TP53, PTEN, CDH1, STK11, and PALB2.
Epigenetic alterations of CDH1 and APC genes: relationship with activation of Wnt/beta-catenin pathway in invasive ductal carcinoma of breast.