cyclin-dependent kinase

(redirected from CDK4 gene)
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cyclin-dependent kinase

[¦sī·klin di¦pen·dənt ′kī‚nās]
(cell and molecular biology)
A family of kinases that, once activated by cyclin, regulate the cell cycle by adding phosphate groups to a variety of protein substrates that control processes in the cycle. Abbreviated Cdk.
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References in periodicals archive ?
Fluorescence in situ hybridization (FISH) analysis for MDM2 and CDK4 gene amplification has been shown in several studies to be both more sensitive and more specific in the diagnosis of ALT/WDL than IHC.
Primary Breast Atypical Lipomatous Tumor: Well-Differentiated Liposarcoma and Dedifferentiated Liposarcoma
To that extent, there is the finding that some specific polymorphisms in the Cdk4 gene could contribute to type 2 diabetes-associated obesity [23].
Role of Ink4a/Arf locus in beta cell mass expansion under physiological and pathological conditions
Elevated level of miR-34a in senescent HDFs was not sufficient to repress CDK4 gene expression.
Expression of senescence-associated microRNAs and target genes in cellular aging and modulation by tocotrienol-rich fraction
This conforms to the results of the CDK4 gene expression, which showed that the extracts were maintaining the cells in a survival mode in cell cycle.
Antioxidative effects of germinated brown rice-derived extracts on [H.sub.2][O.sub.2]-induced oxidative stress in Hepg2 cells

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