white blood cells that contain holes or cavities (observed by microscopic analysis of blood smears), when combined with other findings that indicate NCL, is suggestive for the juvenile form caused by CLN3
Tear, "The Batten disease gene CLN3
is required for the response to oxidative stress," Human Molecular Genetics, vol.
Van Der Kant et al., "Neuronal ceroid lipofuscinosis protein CLN3
interacts with motor proteins and modifies location of late endosomal compartments," Cellular and Molecular Life Sciences, vol.
As a first step towards establishing a general scheme to find hydroxyl radical cleavage patterns that are shared by a set of binding sites of transcription factors, we examined the DNA consensus structural pattern of the yeast Asparagine-rich Zinc-Finger factor AZF1 as an example, which is the glucose-dependent positive regulator of CLN3
transcription in S.
One woman who was asymptomatic and diagnosed by Pap smear had her ClN3
result communicated to her only after a nine-month delay.
At least eight genes have been associated with Batten's disease, but juvenile NCL, the most prevalent form of Batten's disease, has been linked to mutations in the CLN3
The researchers highlighted the fact that Batten disease, which appears in children between ages 4 and 7, is caused by mutations in a gene called CLN3
GENETIC INTERACTIONS BETWEEN THE G1 CYCLIN CLN3
AND TH173 MAY LINK THE ENDOPLASMIC RETICULUM TO REGULATED CELL DIVISION.
CLN1, CLN2 and CLN3
represent a family of cyclins, which are needed for transition from the [G.sub.1] to S phase of the cell cycle.