CMV


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CMV

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In the antenatal period, CMV can be transmitted through vaginal secretions and breast milk.
Current screening programs implemented in some hospitals, called "targeted screening," in which babies who fail newborn screening programs are tested for CMV, are not sufficient to achieve the goal of identifying babies who will need follow-up for early detection of SNHL or vision abnormalities, or possibly early antiviral therapy (Valcyte; valganciclovir), because only a small portion of those who eventually develop SNHL are currently identified by the targeted screening programs.
Caroline Star "For around one in five babies born with congenital CMV, the effects will be devastating - leaving them with lifelong conditions such cerebral palsy and epilepsy.
Instead, a preemptive strategy of monitoring CMV viral load is commonly used to screen for infection or reactivation.
Late-onset disease can also be caused by strains of CMV that have developed resistance to ganciclovir, which then requires the use of more toxic second-line therapies.
According to the company, the Alethia CMV Assay Test System is used as an aid in the diagnosis of congenital CMV infection by detecting CMV deoxyribonucleic acid (DNA) from a saliva swab.
All the samples were screened for CMV specific IgM antibodies by Enzyme Linked Immunosorbent Assay (ELISA) using "Anti-CMV IgM ELISA" kit of Euroimmune following the manufacturer's instructions.
Sera was used for the detection of antibodies (IgG and IgM) specific to CMV using a minividas test (kits/ BioCheck-USA).
While the vast majority of CMV infections are subclinical, that does not mean the virus is inert.
In Nyanza, CMV prevalence is high because of the high rate of HIV in the region.