cox-2 inhibitor

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cox-2 inhibitor:

see nonsteroidal anti-inflammatory drugnonsteroidal anti-inflammatory drug,
a drug that suppresses inflammation in a manner similar to steroids, but without the side effects of steroids; commonly referred to by the acronym NSAID .
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References in periodicals archive ?
The role of COX-2 inhibition in breast cancer treatment and prevention.
As for traditional NSAIDs, the more selective COX-2 inhibition may also contribute to a subsequent surplus of arachidonic acid that can be used by lipoxygenases (Figure 3(b)).
Therefore, we examined whether Sirtl activation is involved in COX-2 inhibition by methyl syringate using a specific inhibitor of Sirtl enzyme activity, sirtinol, whose effects are independent of class I or class III histone deacetylase (Spallotta et al., 2013).
The process of the COX-2 inhibition of apoptosis is possibly connected with the removal of the substrate arachidonic acid by COX-2 catalytic activity or the generation of prostaglandin products.15-20
Studies are a dime a dozen as to "how" COX-2 inhibition reduces arthritic inflammation and menstrual pain and, in so doing, "prevents" certain cancers--most notably of the colon.
It is hypothesized that prolonged high levels of COX-2 inhibition in the plasma can lead to an increased risk of vascular events.
Meloxicam contained in Melonex (c) was used for having long term benefits in suppression of inflammatory responses without gastrointestinal complications for its selective COX-2 inhibition.
Takeuchi, "Role of cyclooxygenase (COX)-1 and COX-2 inhibition in nonsteroidal anti-inflammatory drug-induced intestinal damage in rats: relation to various pathogenic events," The Journal of Pharmacology and Experimental Therapeutics, vol.
Since selective COX-2 inhibition can provide analgesic and antiinflammatory effects with reduced undesirable gastric side effects, COX-2 selective inhibitors such as celecoxib and rofecoxib have become some of the most widely used prescription medications in the developed world.
The maximum COX-2 inhibition induced by KPFV was 43.5% (50 [micro]g/mL); therefore the [IC.sub.50] for COX-2 inhibition was >8.4 x 10-5 M.
Addition of 1 or 10 nM [PGE.sub.2] completely restored HGF mRNA expression suppressed by COX-2 inhibition (Figure 4(b)).
Whether Aceclofenac may have less propensity to cause cardiovascular adverse events due to its preferential COX-2 inhibition (38,39), will need further evaluation.