Editor's Note: "We found 30-day mortality from stroke increased by around 20% if patients were taking a COX-2 inhibitor
before admission," said study co-author Christian Christiansen, PhD, of Aarhus University Hospital.
This equates to about four extra cases of atrial fibrillation per year per 1,000 new users of NSAIDs and seven extra cases among new users of COX-2 inhibitors
Compared with non-users, the association was strongest for new users, with around 40 pc increased risk for non-selective NSAIDS and around 70 pc increased risk for COX-2 inhibitors
All versions of the model are based on estimating the hazard function or the likelihood of a transition (in our case, between nonuse of COX-2 inhibitors
and use of COX-2 inhibitors
) between states at time [DELTA]t, conditional on the spell (of nonuse) having persisted to time t.
On July 1, 2002 Nebraska Medicaid implemented a PAR program for the COX-2 inhibitors
Celebrex[R] (Pfizer Inc.
Between 2004 and 2005, however, in the wake of concerns over the safety of the COX-2 inhibitors
and the subsequent withdrawal of all but one (Celebrex) from the market, the use of these drugs dropped dramatically (from 79.
Selective" COX-2 inhibitors
were developed to avoid the GI complications of traditional NSAIDs, not because they had advantages in terms of pain relief, Antman explained.
The latest study showed that, as expected, COX-2 inhibitors
doubled the risk of an attack but so did NSAIDs.
are effective for the reduction of adenomatous polyps.
This led to the development of COX-2 inhibitors
, which were designed to keep the benefits of inhibiting the COX-2 enzyme but cut out the gastric side-effects linked to the inhibition of COX-1.
The cause of the increase is almost entirely related to new patients taking COX-2 inhibitors
rather than patients switching from their old drugs.
Vioxx, which has the scientific name rofecoxib, was prescribed to 400,000 patients in the UK and belongs to a family of drugs known as Cox-2 inhibitors