Thus emerged a truly new era --the development of natural COX-2 inhibitors
Similarly study in Chandigarh also showed high prescription of selective COX-2 inhibitors
The late 1990s and early 2000s was a period when a significant amount of research was being conducted on the efficacy and side effects of COX-2 inhibitors
Compared with COX-2 inhibitors
, NSAIDs and salicylates have similar efficacy, lower cost, and presumably greater chance for GI side effects.
A 2006 meta-analysis, including 114 trials and 116,094 patients randomized to either cyclooxygenase-2 (COX-2) inhibitor or control (placebo, nonsteroidal anti-inflammatory drug [NSAID], or mixed), indicated that the COX-2 inhibitors
, as a class, had no effect on renal endpoints.
26 in the journal Circulation, an AHA expert panel wrote that further studies have reinforced concerns about COX-2 inhibitors
and also have found an increased risk of cardiovascular events with conventional, nonselective COX-2 NSAIDs, including ibuprofen (Motrin, Advil) and diclofenac (Cataflam, Voltaren).
may increase the risk of heart attacks and strokes for patients taking high doses for long-term treatments, according to studies that led Merck & Co.
Celecoxib can be administered as palliative treatment to affected birds, but as with any nonsteroidal anti-inflammatory drug, COX-2 inhibitors
should be used cautiously because they can adversely affect renal function by decreasing renal prostaglandin synthesis.
Vioxx, which is part of a group of anti-inflammatories known as COX-2 inhibitors
, was banned in 2004 after it was shown that patients on the drug were more than twice as likely to have heart attacks as those not taking it.
When all "vascular events" - heart attacks, stroke, or vascular disease - were taken together, the risks increased by 40pc on COX-2 inhibitors
The latest study showed that, as expected, COX-2 inhibitors
doubled the risk of an attack - but so did the two non-steroidal anti-inflammatories.
Three studies of COX-2 inhibitors
have shown that administration of a COX-2 inhibitor
is associated with a reduction in polyps in high-risk patients.