Inhibitor

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Related to COX-2 inhibitors: Prostaglandins

inhibitor

[in′hib·əd·ər]
(aerospace engineering)
A substance bonded, taped, or dip-dried onto a solid propellant to restrict the burning surface and to give direction to the burning process.
(chemistry)
A substance which is capable of stopping or retarding a chemical reaction; to be technically useful, it must be effective in low concentration.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Inhibitor

 

a circuit having m + n inputs and a single output, at which a signal can appear only when there are no signals on the m inputs (inhibiting). The other n inputs (principal) form one of the two logic connections, “AND” or “OR.” Inhibitors are used extensively in computers. They are very often understood to be a circuit having a single principal input and a single inhibiting input. A signal appears at the output of such a circuit when a signal is present on the principal input but there is none on the inhibiting input. Such an inhibitor is called an anticoincidence gate; its conventional representation is given in Figure 1.

Figure 1. Block diagram of an anticoincidence gate (inhibitor) with m — 1 and n 1:(A) principal input, (Q) inhibiting input, (Ga) anticoincidence gate

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.

inhibitor

A substance added to paint to retard drying, skinning, mildew growth, etc. Also see corrosion inhibitor, inhibiting pigment, drying inhibitor.
McGraw-Hill Dictionary of Architecture and Construction. Copyright © 2003 by McGraw-Hill Companies, Inc.
References in periodicals archive ?
Conflicting results have been obtained in laboratory settings when treatment with a COX-2 inhibitor was administered before or after induced seizures.
Today, there is evidence that natural herbal COX-2 inhibitors obstruct the production of pain and inflammation, while treating other health conditions, in a more friendly, gentle manner--safely and cost-effectively.
Comparable to those in the US survey, almost one-fourth of respondents reported that they would choose COX-2 inhibitors over traditional NSAIDs more commonly during prescribing.
After the Vioxx recall, other painkillers were prescribed to fill the gap, such as celecoxib (Celebrex), another COX-2 inhibitor, nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, aspirin or naproxen, and opioid drugs.
This was the first publication in a major outlet to raise issues about increased risk of myocardial infarction associated with COX-2 inhibitors in general and Vioxx in particular.
This study was focused on those recipients who were taking a COX-2 inhibitor and as a result of the PAR switched to (1) an NSAID or a salicylate and associated costs to treat or prevent GI events with gastroprotectant drug therapy, and (2) another type of pain reliever other than COX-2 inhibitors, NSAIDs, or salicylates.
Following an exhaustive review of systematic reviews and meta-analyses, the authors conclude that COX-2 inhibitors are contraindicated in patients with ischaemic heart disease or stroke.
Cannon said he believed that all COX-2 inhibitors increased that risk.
This may seem onerous considering that Cox-2 inhibitors have typically been prescribed for the treatment of osteoarthritis and rheumatoid arthritis and are mainly used by the elderly, a population exhibiting risk factors for injuries attributed to Cox-2 inhibitor use: heart attacks and strokes.
The study showed that, as expected, anti-inflammatories known as COX-2 inhibitors doubled the risk of an attack, as did NSAIDs
The finding from the largest population study to date on NSAID risk applies not only to selective COX-2 inhibitors, such as celecoxib (Celebrex), but also to nonselective NSAIDs, such as ibuprofen and naproxen.
Celecoxib can be administered as palliative treatment to affected birds, but as with any nonsteroidal anti-inflammatory drug, COX-2 inhibitors should be used cautiously because they can adversely affect renal function by decreasing renal prostaglandin synthesis.