Inhibitor

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Related to COX-2 inhibitors: Prostaglandins

inhibitor

[in′hib·əd·ər]
(aerospace engineering)
A substance bonded, taped, or dip-dried onto a solid propellant to restrict the burning surface and to give direction to the burning process.
(chemistry)
A substance which is capable of stopping or retarding a chemical reaction; to be technically useful, it must be effective in low concentration.

Inhibitor

 

a circuit having m + n inputs and a single output, at which a signal can appear only when there are no signals on the m inputs (inhibiting). The other n inputs (principal) form one of the two logic connections, “AND” or “OR.” Inhibitors are used extensively in computers. They are very often understood to be a circuit having a single principal input and a single inhibiting input. A signal appears at the output of such a circuit when a signal is present on the principal input but there is none on the inhibiting input. Such an inhibitor is called an anticoincidence gate; its conventional representation is given in Figure 1.

Figure 1. Block diagram of an anticoincidence gate (inhibitor) with m — 1 and n 1:(A) principal input, (Q) inhibiting input, (Ga) anticoincidence gate

inhibitor

A substance added to paint to retard drying, skinning, mildew growth, etc. Also see corrosion inhibitor, inhibiting pigment, drying inhibitor.
References in periodicals archive ?
Thus emerged a truly new era --the development of natural COX-2 inhibitors.
Similarly study in Chandigarh also showed high prescription of selective COX-2 inhibitors (32.
The late 1990s and early 2000s was a period when a significant amount of research was being conducted on the efficacy and side effects of COX-2 inhibitors.
Compared with COX-2 inhibitors, NSAIDs and salicylates have similar efficacy, lower cost, and presumably greater chance for GI side effects.
A 2006 meta-analysis, including 114 trials and 116,094 patients randomized to either cyclooxygenase-2 (COX-2) inhibitor or control (placebo, nonsteroidal anti-inflammatory drug [NSAID], or mixed), indicated that the COX-2 inhibitors, as a class, had no effect on renal endpoints.
26 in the journal Circulation, an AHA expert panel wrote that further studies have reinforced concerns about COX-2 inhibitors and also have found an increased risk of cardiovascular events with conventional, nonselective COX-2 NSAIDs, including ibuprofen (Motrin, Advil) and diclofenac (Cataflam, Voltaren).
Cox-2 inhibitors may increase the risk of heart attacks and strokes for patients taking high doses for long-term treatments, according to studies that led Merck & Co.
Celecoxib can be administered as palliative treatment to affected birds, but as with any nonsteroidal anti-inflammatory drug, COX-2 inhibitors should be used cautiously because they can adversely affect renal function by decreasing renal prostaglandin synthesis.
Vioxx, which is part of a group of anti-inflammatories known as COX-2 inhibitors, was banned in 2004 after it was shown that patients on the drug were more than twice as likely to have heart attacks as those not taking it.
When all "vascular events" - heart attacks, stroke, or vascular disease - were taken together, the risks increased by 40pc on COX-2 inhibitors and NSAIDs.
The latest study showed that, as expected, COX-2 inhibitors doubled the risk of an attack - but so did the two non-steroidal anti-inflammatories.
Three studies of COX-2 inhibitors have shown that administration of a COX-2 inhibitor is associated with a reduction in polyps in high-risk patients.