CREB-binding protein


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CREB-binding protein

[¦kreb ¦bin·diŋ ′prō‚tēn]
(cell and molecular biology)
A transcriptional coactivator that binds a phosphorylated domain of cyclic AMP-responsive element binding protein (CREB) to facilitate transcription initiation. Abbreviated CBP.
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References in periodicals archive ?
Park et al., "Transgenic mice expressing a truncated form of CREB-binding protein (CBP) exhibit deficits in hippocampal synaptic plasticity and memory storage," Learning & Memory, vol.
CREB-binding protein controls response to cocaine by acetylating histones at the fosB promoter in the mouse striatum.
cAMP-dependent protein kinase type I regulates ethanol-induced cAMP response element-mediated gene expression via activation of CREB-binding protein and inhibition of MAPK.
The nuclear bodies contain, in addition to PML (in normal individuals), several important regulatory proteins including SUMO-1 (see next page), CREB-binding protein, retinoblastoma-susceptibility gene product (pRB), the death-domain-associated protein (Daxx), and p53.
Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-l to hypoxia-inducible factor 1[alpha].
Fernandez, "The induction of IL-10 by zymosan in dendritic cells depends on CREB activation by the coactivators CREB-binding protein and TORC2 and autocrine PGE2," The Journal of Immunology, vol.
observed that GSK-3[beta] regulated the production of proinflammatory and anti-inflammatory cytokines by LPS-stimulated monocytes via augmenting nuclear CREB activity and enhancing its association with CREB-binding protein while reducing the interactions between NF-[kappa]B p65 and CBP [15].