CREB-binding protein

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CREB-binding protein

[¦kreb ¦bin·diŋ ′prō‚tēn]

(cell and molecular biology)

A transcriptional coactivator that binds a phosphorylated domain of cyclic AMP-responsive element binding protein (CREB) to facilitate transcription initiation. Abbreviated CBP.

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Transgenic mice expressing a truncated form of CREB-binding protein (CBP) exhibit deficits in hippocampal synaptic plasticity and memory storage.

Mecanismos intracelulares involucrados en el aprendizaje y la memoria del miedo

The researchers found that dietary restriction induces a transcription factor called CREB-binding protein (CBP), which controls the activity of genes that regulate cellular function.

Molecular trigger that helps prevent aging and disease found

The nuclear bodies contain, in addition to PML (in normal individuals), several important regulatory proteins including SUMO-1 (see next page), CREB-binding protein, retinoblastoma-susceptibility gene product (pRB), the death-domain-associated protein (Daxx), and p53.