These proteins are important in neuronal differentiation, and regeneration proteins like ACTB, GSK3B, CREB1
, and CTNNB1 have physical interaction with coexpressed proteins .
UCA1, upregulated in CRC, inhibited miR-204-5p activity, thus promoting the upregulation of miRNA targets CREB1
, BCL2, and RAB22A (RAB22A, member RAS oncogene) and regulating cell proliferation and apoptosis .
switches on another group of molecules linked to longevity called "sirtuins".
Doctor Giovambattista Pani, at the Catholic University of Sacred Heart, said: "Our hope is to find a way to activate CREB1
. For example, through new drugs, so to keep the brain young without a strict diet."
Learning-dependent gene expression of CREB1
isoforms in the molluscan brain.
Genotyping identified all single nucleotide polymorphisms in a region that contained the CREB1
A previous study showed that MSCs could generate IPCs using mouse neonate pancreas extract, by expressing genes related to [beta]-cells (PDX1, INS1, INS2, EP300, and CREB1
), and found a dialogue between the FOXA2 and TCF7L2 transcription factors .
In addition to its repressing function, our knowledge of MeCP2 has increased overtime, and it is now known that MeCP2 can interact with coactivator cyclic AMP-responsive element-binding protein 1 (CREB1
) to activate the expression of its target genes, alternate splicing sites via an interaction with YB1, a Y-box transcription factor, or regulate microRNA (miRNA) processing by interacting with DGCR8 to prevent the formation of the Drosha-DGCR8 complex .
However, with evaluation of one additional step, a plausible mechanism was revealed: CREB1
can be activated by PCB 153 through the PXR (inhibition of an inhibitor) via documented direct binding interactions (Kodama et al.
In 2006, Antonescu et al (1) reported 3 of 3 cases of CCSLGT as showing translocations involving chromosomes 22 and 2 instead, resulting in fusions between EWSR1 and the CREB1
AhR has been shown to regulate Ltbp-1 transcription by a mechanism involving recruitment of coactivators such as CREB1
and corepressors such as HDAC2 to the Ltbp-1 promoter .
Among factors demonstrated to target this region, CREB1
factor was described by the group of Peter van den Elsen to bind two cAMP response elements (CRE) at positions -1381 and -1371 (3' ends) from the ATG .