CREB

(redirected from CREB1)
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Related to CREB1: CREBBP, CREBP, KREB, CREB binding protein

CREB

[¦sē¦är¦ē′bē or kreb]
(cell and molecular biology)
References in periodicals archive ?
These proteins are important in neuronal differentiation, and regeneration proteins like ACTB, GSK3B, CREB1, and CTNNB1 have physical interaction with coexpressed proteins [58].
UCA1, upregulated in CRC, inhibited miR-204-5p activity, thus promoting the upregulation of miRNA targets CREB1, BCL2, and RAB22A (RAB22A, member RAS oncogene) and regulating cell proliferation and apoptosis [137].
CREB1 switches on another group of molecules linked to longevity called "sirtuins".
Doctor Giovambattista Pani, at the Catholic University of Sacred Heart, said: "Our hope is to find a way to activate CREB1. For example, through new drugs, so to keep the brain young without a strict diet."
Learning-dependent gene expression of CREB1 isoforms in the molluscan brain.
Genotyping identified all single nucleotide polymorphisms in a region that contained the CREB1 gene.
A previous study showed that MSCs could generate IPCs using mouse neonate pancreas extract, by expressing genes related to [beta]-cells (PDX1, INS1, INS2, EP300, and CREB1), and found a dialogue between the FOXA2 and TCF7L2 transcription factors [30].
In addition to its repressing function, our knowledge of MeCP2 has increased overtime, and it is now known that MeCP2 can interact with coactivator cyclic AMP-responsive element-binding protein 1 (CREB1) to activate the expression of its target genes, alternate splicing sites via an interaction with YB1, a Y-box transcription factor, or regulate microRNA (miRNA) processing by interacting with DGCR8 to prevent the formation of the Drosha-DGCR8 complex [44].
However, with evaluation of one additional step, a plausible mechanism was revealed: CREB1 can be activated by PCB 153 through the PXR (inhibition of an inhibitor) via documented direct binding interactions (Kodama et al.
In 2006, Antonescu et al (1) reported 3 of 3 cases of CCSLGT as showing translocations involving chromosomes 22 and 2 instead, resulting in fusions between EWSR1 and the CREB1 gene.
AhR has been shown to regulate Ltbp-1 transcription by a mechanism involving recruitment of coactivators such as CREB1 and corepressors such as HDAC2 to the Ltbp-1 promoter [44].
Among factors demonstrated to target this region, CREB1 factor was described by the group of Peter van den Elsen to bind two cAMP response elements (CRE) at positions -1381 and -1371 (3' ends) from the ATG [76].