CBP

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Related to CREBBP: EP300

CBP

(cell and molecular biology)
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The mRNA level of histone acetyltransferases gene (P300 and CREBBP) and histone demethylases gene (HDAC1, HDAC2, and HDAC7) was detected by RT-PCR.
Levels of OCT4 and CDX2 as well as CREBBP, JUN, ETS2 and IFNT mRNAs in peri-implantation conceptuses were examined by PCR using specific primers (Table 1).
Exon deletions of the EP300 and CREBBP genes in two children with Rubinstein-Taybi syndrome detected by aCGH.
(13, 14) One study from South Korea by Jung et al (14) reported that TNFAIP3 is the most frequently mutated gene followed by TBL1XR1 and CREBBP, and the MYD88 mutation was detected only in 4% of patients.
In this study, the easy-made targeting vectors are aided by the CRISPR/Cas9 technique to insert LoxP elements on the flanking regions of the targeted loci sequentially or simultaneously, by which conditional gene knockouts are generated, such as Eed (embryonic ectoderm development) and SRCAP (Snf2-related CREBBP activator protein) in mouse embryonic stem cells (mESCs).
Cytoplasmic IRF-3 is inactive unless phosphoactivation of IRF-3 triggers unfolding of the autoinhibitory elements and exposes the hydrophobic surface to interaction with CREBBP to translocate to the nucleus [60].