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Methods: Meso scale discovery system and commercial ELISA kits were used to measure the concentrations of proinflammatory cytokines interleukin (IL)-1[sz]; tumor necrosis factor-alpha (TNF-a); IL-6; and IL-17 and CC and CXC chemokines CCL2, CCL4, CCL11, CCL13, CCL17, CCL22, and CCL26 and CXCL8, CXCL9, CXCL10, and CXCL11 in bronchoalveolar lavage fluid of asthmatics and controls.
10) They then found that, as expected, gastric and colonic epithelial cells stimulated with NOD1 ligand induced robust production of IFN-[beta] and neutralization of the type I IFN signaling pathway by blockade of the IFN[alpha][beta] receptor resulted in a marked reduction of CXCL10 expression.
12,14] Induction of the IFN-[alpha]-inducible CXCR3 ligands, CXCL9, CXCL10 and CXCL  has been reported.
Research published in The American Journal of Pathology shows that one of the protein receptors on white blood cells, CXCR3, brings white blood cells to the optic nerve after damaged nerve tissue produces the binding partner, CXCL10.
5) In TB disease, Th17 primarily exerts its protective effect through IL-17, which recruits neutrophils to promote granuloma formation, (6) and increases the expression of chemokines, CXCL9, CXCL10, and CXCL11, which recruit IFN-[gamma] producing cells to the infected site.
These genes encoded cytokines (CSF3, CSF2, CCL3, TNF, CCR1, IL13, KIT, CCL5, CCL4, IL10, CXCL10, IL12RB2, IFNG, IL1B, IL1A, IL8, MET, CD40, HGF, LEP, CXCL16, CX3CR1, CCR2, PDGFRA, IL12B, IL2), lipid metabolism related genes (CD36, GPX4, LPIN1, LPL, LPB), transcription regulators (BCL3, FOS and NFKBIA), receptors (TNF, IL8, RELA, TLR1, TIRAP, TLR2, NFKBIA, NFKB1, TLR4, CD40, CCL5, CXCL10, FOS, JUN, MAP3K8, IL1B, LBP, IL12B, CD14, SPP1), and others such as SELP, SELL, and SOD1, all play a role in some aspect of the immune response including cytokine activity (IL10, TNF, IL8, and IL1B), cell adhesion (SELL and SELP), immune activation (CD14 and TLR2), acute phase reaction (TNF, IL1B, and SAA3), apoptosis (BCL2, BAX).
3] also caused greater increases in BAL CXCL1, IL-6, IL-2, eotaxin (CCL11), CSF3, IL-1a, IL-10, IL-12 (p40), CXCL10, LIF, RANTES, CXCL9, and CCL4 in the same cohort of [O.
Regarding the role of IFN[gamma] in the autoimmune process of HT, this effector acts as an amplification enhancer of CXCL10 Th1 modulated (the prototype of the IFN[gamma]-inducible Th1 chemokines) [37,38].
Elevated levels of CXCL10 in the Periodic Fever, Aphthous stomatitis, Pharyngitis and cervical Adenitis syndrome (PFAPA) during and between febrile episodes; an indication of a persistent activation of the innate immune system.
In the current study, it was noted that CXCL10 was released from both endothelial and epithelial cells, and it then bound to CXCR3 receptors.
2008); CXCL10, known to have a pathogenic role in bone destruction and osteodastogenesis possibly by mediating increases in RANKL expression (Lee et al.
In addition, CXCL10 secreted from [beta]-cells activates and attracts autoreactive T cells and macrophages to the islets via CXCR3, and the infiltrating autoreactive T cells and macrophages release inflammatory cytokines, thus activating cell-mediated autoimmunity in islet and accelerating [beta]-cell destruction in FT1D .
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