brak

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brak

South African a mongrel dog
Collins Discovery Encyclopedia, 1st edition © HarperCollins Publishers 2005

Brak

(pop culture)
“Hi,my name is Braaaak!”—not the bloodcurdling introduction one might expect of an interstellar pirate, but with this member of Space Ghost's rogues' gallery, one must expect the unexpected. First seen in “The Looters,” a Space Ghost episode (original airdate: October 22, 1966) of Hanna-Barbera's original Space Ghost and Dino Boy series (1966–1968), Brak, voiced by Keye Luke, and his fellow pirates overtake a goldtransport spacecraft with their sleep-inducing gas. Capturing Space Ghost's interloping sidekicks, Brak ultimately wars with the crusading superhero when he comes to their rescue. The saber-toothed space thief who hides his features behind a catlike helmet often wields a ray pistol in his crimes, and he struggled with Space Ghost in animated episodes and in a 1987 Space Ghost comic book. The irreverent cable-TV comedy Space Ghost: Coast to Coast (1994–2004) recast the superhero into a talk-show host who interviewed real-life celebrities, with foes Zorak, Moltar, and the formerly fearsome but now loopy Brak (voiced by Andy Merrill) brought on board as a threesome “Paul Shaffer” to Space Ghost's “David Letterman.” Brak, a notorious moocher whose pirating was now limited to food raids in the television studio, ultimately wormed his way to co-host status on Coast to Coast before landing his own 2000 short-lived variety show, Brak Presents the Brak Show Starring Brak, followed by The Brak Show (2000–2003), an animated sitcom seen in the Cartoon Network's “Adult Swim” programming block. In this Space Ghost prequel, grade-schooler Brak was a supervillain-in-the-making living in suburbia with his human father, bewitching catlike mother, and wind-breaking brother Sisto, and attending class with Zorak and 1960s Hanna-Barbera toon star Wally Gator. The offbeat show's plots involved everything from a putting on a neighborhood musical (with guest-star Charo) to battling Thundercleese, the robot that lived next door. The Brak Show merchandising included a 2005 DVD collection and actionfigure set; in his Coast to Coast incarnation, Brak appeared as an action figure and a maquette.
The Supervillain Book: The Evil Side of Comics and Hollywood © 2006 Visible Ink Press®. All rights reserved.
References in periodicals archive ?
Xu et al., "Suppression of antitumor immune responses by human papillomavirus through epigenetic downregulation of CXCL14," MBio, vol.
Nakashima, "CXCL14 and MCP1 are potent trophic factors associated with cell migration and angiogenesis leading to higher regenerative potential of dental pulp side population cells," Stem Cell Research & Therapy, vol.
The expression of CXCL14 increased significantly only in adipose and thymus of TCDD-treated wt mice.
In addition, the expression of 7 cytokines genes (IL-22, VEGFA, IL26, CXCL14, BMPER, IL-17D, and CCL20) and 16 receptor genes (IL-22RA1, CXCR3, IL-17RC, IL-1RAPL2, IFITM5, NRG2, TNFRSF14, LEPREL2, IL-11RA, LTBP2, ILDR1, IL-17RD, MC1R, IL-22RA2, LEPREL1, and LILRA5) were significantly downregulated by 3.6- to 5.7-fold and 2.14- to 9.12-fold, respectively with p < 0.01 and fold [greater than or equal to] 2 (Figures 4 and 5).
Using a 1-tail sign test with P value <0.01, 6 markers showed statistically significant increases in staining codes for the prostate cancer tissue compared to the matched control tissue [collagen type 2, al (COL2A1), cartilage oligomeric matrix protein (COMP), chemokine (C-X-C motif) ligand 14 (CXCL14), ephrinA4 (EFNA4), G protein-coupled receptor 116 (GPR116), and PCSK6].
It has been shown in vitro that angiostatic factors, such as thrombospondin-1 and the chemokines CXCL4 and CXCL14, appear to enhance DC maturation and APC function.
CAFs produce CCL2, CCL5, CCL7, CXCL8, and CXCL14 and these chemokines promote tumor progression mainly by enhancing the motility of tumor cells [48].