hlp

(redirected from CYP3A4)
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hlp

(filename extension)
A Microsoft Windows filename extension for hypertext WinHelp files. These are in a proprietary format, and are compiled from source files written in a dialect of RTF.

See also gid.

Usenet newsgroup: news:comp.os.ms-windows.programmer.winhelp.
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References in periodicals archive ?
27,28) These interactions occur due to AED induction of the CYP3A4 enzyme and effects on the P-glycoprotein (P-gp) efflux pump.
Methods: To determine the role of CYP3A4 and CYP3A5 on tacrolimus metabolism, rats were divided into five groups as: group 1 (control group, tacrolimus only 1 mg/kg i.
CYP3A4 accounts for about 30% in the human hepatic metabolism of xenobiotics.
Primarily, S-warfarin is metabolized by CYP2C9 and R-warfarin by CYP3A4, CYP1A2, and CYP1A1.
2) Secondly, one should recognize the potential CYP3A4 competitive inhibition when using RTV and an azolic agent.
when the drug is taken in conjunction with moderate or strong CYP3A4 inhibitors or by patients with hepatic impairment.
No dosage adjustment is required for dexamethasone, a CYP3A4 substrate, when administering VARUBI, said the company.
Assurance that prescribers would be fully apprised of the serious risks of hypotension and syncope associated with the drug, exacerbation of those side effects when combined with alcohol or a CYP3A4 inhibitor--and the modest effects over placebo --was cited by several of the panelists who voted in favor of approval.
Oral contraceptives, weak CYP3A4 inhibitors, were allowed in the three studies, but other CYP3A4 inhibitors, including fluticasone and grapefruit, were among the exclusion criteria.
In humans, MA only weakly inhibited CYP3A4 activity in human liver microsomes and specific CYP3A4 isoform with [IC.
Endometrial oestrogen metabolism occurs through CYP1A1, CYP1B1 and CYP3A4, with CYP3A4 being more abundant on endometrial cells.