Cachexia


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cachexia

[ka′kek·sē·ə]
(medicine)
Weight loss, weakness, and wasting of the body encountered in certain diseases or in terminal illnesses.

Cachexia

 

a state of profound wasting and physical debility manifested by severe emaciation, weight loss, dry and flabby skin, loss of hair, disappearance of subcutaneous fat, atrophy of muscles and viscera, and low serum protein level. Edema, hemorrhages, and sometimes mental derangement can occur with cachexia. It results from prolonged malnutrition or starvation, severe metabolic disorders, chronic arsenic, lead, mercury, or fluorine poisoning, and severe lesions of the digestive tract (atrophy of the intestinal mucosa, condition after resection of the stomach and intestines). Cachexia may occur in severe cases of tuberculosis or other chronic infections, some lesions of the endocrine glands, (hypophysis, thyroid, adrenals, pancreas), large slow-healing wounds, abscesses, and malignant tumors (especially of the esophagus and stomach).

References in periodicals archive ?
The prominent feature in cachexia is weight loss and muscle wasting that leads to progressive functional impairment.
The use of antioxidants in cancer and cachexia has always been a polemical issue, hence the need to gather the main existing knowledge in an attempt to answer a number of essential questions and improve our understanding on this topic: how can the undifferentiated use of supplements by cancer patients impact tumor and anticancer treatment?
The report reviews key players involved in the therapeutics development for Cachexia and enlists all their major and minor projects
All these experiments indicate that parthenolide could decrease NE-[kappa]B binding activity and inhibit inflammatory cytokine production, and thus may reduce tumor burden and alleviate cachexia symptoms.
Cancer cachexia is a wasting syndrome characterized by loss of muscle and fat, and occurs in the majority of patients with advanced, refractory malignancies.
Serum carnitine levels in patients with tumoral cachexia.
Since cachexia is often triggered by inflammation, Gallouzi theorized that the anti-inflammatory properties of pateamine A might protect against muscle wasting.
Reid and colleagues report the results of a survey involving 15 patients with advanced cancer and cachexia and 12 family members.
No further mortality related to cachexia and hepatosplenomegaly occurred in the flock during the subsequent 24 months.
Previous studies have suggested that cachexia is responsible for between one-fifth and one-third of all cancer deaths.
Apart from cachexia in most animals, bronchopneumonia was the main macroscopic lesion (in 31 chamois); 4 had diarrhea, 2 had infectious keratocojunctivitis, 2 had an abscess, and 1 had severe fibrinous pleuropericarditis.
Cardiac cachexia is weight loss due to the debilitating condition of heart failure.