cadherin


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cadherin

[kad′hir·en]
(cell and molecular biology)
Any of a family of calcium-dependent cell adhesion glycoproteins that play a fundamental role in tissue differentiation and structure.
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Expression of epithelial cadherin and cavernous sinus invasion in human pituitary adenomas.
To examine the mode of binding, binding stability and interaction profiles of ligand and receptor proteins, all mutant proteins were subjected to docking with Helicoverpa armigera Cadherin and APN receptors and Aedes aegypti ALP by clusPro(2.
During this process, E-cadherin, a hallmark of the epithelial phenotype, is downregulated, while neural cadherin (N-cadherin), normally expressed in fibroblasts, is upregulated (Thiery et al.
Oas RG, Nanes BA, Esimai CC, Vincent PA, Garcia AJ, Kowalczyk AP p 120-catenin and [beta]-catenin differentially regulate cadherin adhesive function.
3,12,13] The cadherins comprise a large number of adhesion molecules localized in the intercellular junctions, keeping cells connected through homophilic protein-protein interactions.
Of these, the first two belong to the adherens junctions, where the adhesion molecules cadherin and catenin are present.
Expression of cadherin cell adhesion molecules during human skin development: morphogenesis of epidermis, hair follicles and sweat ducts.
1) between cadherin 10 (CDH10) and cadherin 9 (CDH9), two genes that encode neuronal cell-adhesion molecules.
signaling), cell matrix adhesions in three dimensions, cell-cell junctions, signaling to and through the endothelial adherens junction, gap junctions (connexin functions), tight junctions in simple and stratified epithelium, desmosomes in development and disease, cadherin trafficking and junction dynamics, and cross-talk in cell-cell and cell-matrix adhesions.
These results raise the possibility that differences in cadherin and catenin expression levels and localization may contribute to the difference in the susceptibility of various nephron segments to renal pathology or nephrotoxic injury.