in brain morphogenesis and wiring," Physiological Reviews, vol.
Expressed recombinant cadherins
mediate cell sorting in model systems.
Transcriptional regulation of cadherins
during development and carcinogenesis.
[Expression of liver-intestine cadherin
in gastric cancer and its relationship with progonsis].
[15.] Andrews JL, Kim AC, Hens JR: The role and function of cadherins
in the mammary gland.
E-cadherin, one of the classic cadherins
, playing a major role in the establishment and maintenance of intercellular adhesion, cell polarity, and tissue architecture , has been implicated in carcinogenesis because it is frequently lost or downregulated in human epithelial cancers including prostate, breast, bladder, pancreas, stomach, and colon tumors [26-30].
The establishment of apical-basal polarity depends on the cooperation of proteins such as Crb3 (Crumbs homolog 3), hDlg (human Discs large), Par3/Par6, and the cadherins
, among others.
E-cadherin, one subtype of Cadherins
family, is the adhesion molecule found in mammalian cells which is an important factor in cell-cell adhesion.
The classical cadherins
consist of E (epithelial), N (neuronal) and P (placental) cadherin
, which are the best studied representatives of this family.
Desmogleins are calcium-binding transmembrane glycoproteins, members of the desmosomal cadherins
that provide adhesive integrity to desmosomes between adjoining keratinocytes; They consist of proteins Dsg1, Dsg2, Dsg3, and Dsg4.