cadherin

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cadherin

[kad′hir·en]
(cell and molecular biology)
Any of a family of calcium-dependent cell adhesion glycoproteins that play a fundamental role in tissue differentiation and structure.
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Takeichi, "Cadherins in brain morphogenesis and wiring," Physiological Reviews, vol.
[Expression of liver-intestine cadherin in gastric cancer and its relationship with progonsis].
[15.] Andrews JL, Kim AC, Hens JR: The role and function of cadherins in the mammary gland.
E-cadherin, one of the classic cadherins, playing a major role in the establishment and maintenance of intercellular adhesion, cell polarity, and tissue architecture [25], has been implicated in carcinogenesis because it is frequently lost or downregulated in human epithelial cancers including prostate, breast, bladder, pancreas, stomach, and colon tumors [26-30].
The establishment of apical-basal polarity depends on the cooperation of proteins such as Crb3 (Crumbs homolog 3), hDlg (human Discs large), Par3/Par6, and the cadherins, among others.
E-cadherin, one subtype of Cadherins family, is the adhesion molecule found in mammalian cells which is an important factor in cell-cell adhesion.
The classical cadherins consist of E (epithelial), N (neuronal) and P (placental) cadherin, which are the best studied representatives of this family.
Desmogleins are calcium-binding transmembrane glycoproteins, members of the desmosomal cadherins that provide adhesive integrity to desmosomes between adjoining keratinocytes; They consist of proteins Dsg1, Dsg2, Dsg3, and Dsg4.