On the other hand, aAVC loaded with full-length cancer antigens
are applicable for many patients regardless of their HLA types.
That makes sense, Carter said, since cancer antigens
that are presented by MHC-I would lead to early elimination of those cancer cells by T cells.
As shown in Figure 3, the host antigen comes into direct contact with the transplanted thymus from renal capsules, in which it is translated, whereas cancer antigens
are relatively isolated from and do not come into direct contact with the transplanted thymus, as tumor cells were transplanted subcutaneously into the backs of the experimental animals [8-10].
immatics' unique and world-leading technology platform XPRESIDENT discovers novel relevant cancer antigens
known to be expressed on tumor cells.
The XPRESIDENT discovery platform is to date the only known high-throughput research technology to directly identify, quantify, and prioritize cancer antigens
recognized by T lymphocytes (type of white blood cell) based on the ability of the immune system to detect them.
ImmunoCellular's pipeline also includes ICT-121, a dendritic cell vaccine targeting CD 133, and ICT-140, a dendritic cell vaccine targeting ovarian cancer antigens
and cancer stem cells.
The Randox Acusera multi-analyte Liquid Tumour Marker Control covers a total of 15 commonly tested and esoteric cancer antigens
and tumor markers.
This meant that the immune system 'self-selected' the cancer antigens
to respond to and did not react against other healthy parts of the body.
Some important cancer antigens
that serve as diagnostic and prognostic biomarkers of cancer are summarized in the Table.
We fight cancer with immunotherapy by creating antibodies against cancer antigens
"The GM-CSF molecule attracts immune cells to the vaccine site, where the immune cells encounter pancreas cancer antigens
. They then patrol the rest of the patient's body in a kind of seek and destroy mission, to destroy pancreas tumor cells possessing the same antigen profile," Dr.
"With the licensing of this important portfolio of clinically-validated cancer antigens
, we strengthen our commitment to developing innovative immunotherapies against a wide variety of oncology targets, employing our unique APC targeted delivery methodology."