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Related to Cancer cachexia: paraneoplastic syndrome


Weight loss, weakness, and wasting of the body encountered in certain diseases or in terminal illnesses.



a state of profound wasting and physical debility manifested by severe emaciation, weight loss, dry and flabby skin, loss of hair, disappearance of subcutaneous fat, atrophy of muscles and viscera, and low serum protein level. Edema, hemorrhages, and sometimes mental derangement can occur with cachexia. It results from prolonged malnutrition or starvation, severe metabolic disorders, chronic arsenic, lead, mercury, or fluorine poisoning, and severe lesions of the digestive tract (atrophy of the intestinal mucosa, condition after resection of the stomach and intestines). Cachexia may occur in severe cases of tuberculosis or other chronic infections, some lesions of the endocrine glands, (hypophysis, thyroid, adrenals, pancreas), large slow-healing wounds, abscesses, and malignant tumors (especially of the esophagus and stomach).

References in periodicals archive ?
A review of the Cancer Cachexia products under development by companies and universities/research institutes based on information derived from company and industry-specific sources
43 g) group were significantly decreased and this indicated that parthenolide could reduce cancer burden and slowed down the process of cancer cachexia.
L-carnitine ameliorates cancer cachexia in mice by regulating the expression and activity of carnitine palmityl transferase.
Cytokines and nutritional response in cancer cachexia.
As skeletal muscle wasting is a key feature of cancer cachexia, hereafter, we will focus and describe main ROS-dependent mechanisms involved in muscle proteolysis and the interplay between tumor and muscle.
Coverage of the Cancer Cachexia pipeline on the basis of route of administration and molecule type.
This action strongly decreases the overactivity of UPS, which may be the most important component of cancer cachexia.
11) EPA may also counter cancer cachexia through its anti-inflammatory effects and its ability to displace arachidonic acid, a pro-inflammatory omega-6 fatty acid, from cell membranes.
A Steering Committee of dietitians with research expertise in nutritional management of cancer cachexia and evidence based guideline development produced the first draft of the clinical practice guidelines.
Cancer Cachexia Global Clinical Trials Review, H1, 2013" provides data on the Cancer Cachexia clinical trial scenario.
The ROMANA 1 and ROMANA 2 phase III studies clinically demonstrated that anamorelin significantly improved, in respect to placebo, lean body mass and body weight, in addition to symptom burden, including appetite, in NSCLC patients with Cancer Cachexia.
M2 PHARMA-November 28, 2011-Aeterna Zentaris announces IND approval for Phase IIa cancer cachexia trial(C)2011 M2 COMMUNICATIONS

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