have also found changes in carbamoyl phosphate
1 expression in IUGRs.
In the urea cycle, OTC combines ornithine and carbamoyl phosphate
to form citrulline.
(1,2) This antigen was shown to be carbamoyl phosphate
synthetase 1, an enzyme involved in urea synthesis.
To overcome any serendipity, positive controls such as acetyl phosphate, carbamoyl phosphate
, dihydroxyacetone-P, phosphoramidate, and monophosphoimidazole were used throughout the docking procedure.
Understanding carbamoyl phosphate
synthetase deficiency: impact of clinical mutations on enzyme functionality.
OTC [EC: 18.104.22.168], a mitochondrial enzyme expressed in liver and gut, catalyzes the condensation of ornithine with carbamoyl phosphate
to form citrulline within the urea cycle.