Carbonic Anhydrase


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carbonic anhydrase

[kär′bän·ik an′hī‚drās]
(biochemistry)
An enzyme which aids carbon dioxide transport and release by catalyzing the synthesis, and the dehydration, of carbonic acid from, and to, carbon dioxide and water.

Carbonic Anhydrase

 

carboanhydrase, carbonate hydrolase, an enzyme of the lyase class that catalyzes the reversible formation of carbonic acid from carbon dioxide and water: CO2 + H 2O ⇄H2CO3.. Carbonicanhydrase is a metallo-protein containing zinc. Molecular weight, about 30, 000.

Carbonic anhydrase is found in erythrocytes and in cells of the kidneys, the gastric mucosa, and the retina of the eye. Erythrocytic carbonic anhydrase provides for the bonding of CO2with blood in the tissues and for its rapid release in the lungs or branchia. Carbonic anhydrase makes for the formation of acid urine in the kidney, hydrochloric acid in the gastric mucosa, bicarbonates of pancreatic juice in the pancreas, and eggshells (containing CaCO3) in the oviducts of birds. Carbonic anhydrase is specifically and strongly inhibited by sulfonamides, which contain an aromatic group. Diamox (acetazolamide), Pentazane (methazolamide), and other agents used in the treatment of glaucoma and diseases of the retina and nervous system are examples of especially active carbonic anhydrase inhibitors. Carbonic anhydrase also occurs in the leaves of certain plants.

E. IU. CHENYKAEVA

References in periodicals archive ?
Quantitative changes in branchial carbonic anhydrase activity and expression in the euryhaline green crab, Carcinus maenas, in response to low salinity exposure.
Recognizing that the enzymatic processes in biomineralization are broadly conserved within Metazoa (Le Roy et al., 2014), we hypothesized that carbonic anhydrase (CA) genes were expressed in tissues involved in biomineralization in tube-building serpulids.
Treatment with all tested drugs (ES-EG or HCTZ) did not change the erythrocyte carbonic anhydrase activity, while the administration of acetazolamide, a classic carbonic anhydrase inhibitor, reduced it by 46 [+ or -] 7%.
Case 4###72###Male###Right###Beta blocker, , alpha agonist, Carbonic anhydrase inhibitors, Prostaglandin analouge
(8.) Epstein RJ, Allen RC, Lunde MW Organic impotence associated with carbonic anhydrase inhibitor therapy for glaucoma.
Carbonic anhydrase inhibitors and ventilation: a complex interplay of stimulation and suppression.
As the second step, the reversed-phase retention times of insulin, aprotinin, cytochrome c, ribonuclease, a-lactalbumin, lysozyme, myoglobin, [beta]-lactoglobulin, elastase, carbonic anhydrase, peroxidase, albumin, enolase, and L-glutamic dehydrogenase were determined using the two linear gradients method (with different gradient times).
The reason appears to be related to an enzyme in the body called carbonic anhydrase, which relies on zinc for proper functioning.
NPPC and carbonic anhydrase 12 (CA12) were validated as Gen-induced genes, and interestingly, Dex antagonized Gen-induction for both genes.
Swelling of the crystalline lens due to the alterations in the sodium and chloride movement caused by weak carbonic anhydrase inhibitor activity of topiramate has been postulated.