Carbonic Anhydrase

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carbonic anhydrase

[kär′bän·ik an′hī‚drās]
An enzyme which aids carbon dioxide transport and release by catalyzing the synthesis, and the dehydration, of carbonic acid from, and to, carbon dioxide and water.

Carbonic Anhydrase


carboanhydrase, carbonate hydrolase, an enzyme of the lyase class that catalyzes the reversible formation of carbonic acid from carbon dioxide and water: CO2 + H 2O ⇄H2CO3.. Carbonicanhydrase is a metallo-protein containing zinc. Molecular weight, about 30, 000.

Carbonic anhydrase is found in erythrocytes and in cells of the kidneys, the gastric mucosa, and the retina of the eye. Erythrocytic carbonic anhydrase provides for the bonding of CO2with blood in the tissues and for its rapid release in the lungs or branchia. Carbonic anhydrase makes for the formation of acid urine in the kidney, hydrochloric acid in the gastric mucosa, bicarbonates of pancreatic juice in the pancreas, and eggshells (containing CaCO3) in the oviducts of birds. Carbonic anhydrase is specifically and strongly inhibited by sulfonamides, which contain an aromatic group. Diamox (acetazolamide), Pentazane (methazolamide), and other agents used in the treatment of glaucoma and diseases of the retina and nervous system are examples of especially active carbonic anhydrase inhibitors. Carbonic anhydrase also occurs in the leaves of certain plants.


References in periodicals archive ?
Quantitative changes in branchial carbonic anhydrase activity and expression in the euryhaline green crab, Carcinus maenas, in response to low salinity exposure.
Carbonic anhydrase (CA IX) expression, a potential new intrinsic marker of hypoxia: Correlations with tumor oxygen measurements and prognosis in locally advanced carcinoma of the cervix.
2014), we hypothesized that carbonic anhydrase (CA) genes were expressed in tissues involved in biomineralization in tube-building serpulids.
Treatment with all tested drugs (ES-EG or HCTZ) did not change the erythrocyte carbonic anhydrase activity, while the administration of acetazolamide, a classic carbonic anhydrase inhibitor, reduced it by 46 [+ or -] 7%.
Case 3###70###Female###Left###Beta blocker, Carbonic anhydrase inhibitors, Prostaglandin analogue,, alpha agonist
Epstein RJ, Allen RC, Lunde MW Organic impotence associated with carbonic anhydrase inhibitor therapy for glaucoma.
Carbonic anhydrase inhibitors and ventilation: a complex interplay of stimulation and suppression.
The sorption of proteins such as insulin, aprotinin, [alpha]-lactalbumin, ribonuclease, myoglobin, carbonic anhydrase, peroxidase, and enolase was largely unaffected by the sorbent when the mobile phase organic solvent used was acetonitrile.
Blood tests showed that the lowzinc diet lowered the men's stores of the mineral, and diminished the activity of the carbonic anhydrase enzymes in their red blood cells.
Effects of glucocorticoid treatment of the carbonic anhydrase activity of brain tissue in the early postnatal age in the rat.
Swelling of the crystalline lens due to the alterations in the sodium and chloride movement caused by weak carbonic anhydrase inhibitor activity of topiramate has been postulated.