Carbonic Anhydrase

Also found in: Dictionary, Thesaurus, Medical, Acronyms, Wikipedia.

carbonic anhydrase

[kär′bän·ik an′hī‚drās]
An enzyme which aids carbon dioxide transport and release by catalyzing the synthesis, and the dehydration, of carbonic acid from, and to, carbon dioxide and water.

Carbonic Anhydrase


carboanhydrase, carbonate hydrolase, an enzyme of the lyase class that catalyzes the reversible formation of carbonic acid from carbon dioxide and water: CO2 + H 2O ⇄H2CO3.. Carbonicanhydrase is a metallo-protein containing zinc. Molecular weight, about 30, 000.

Carbonic anhydrase is found in erythrocytes and in cells of the kidneys, the gastric mucosa, and the retina of the eye. Erythrocytic carbonic anhydrase provides for the bonding of CO2with blood in the tissues and for its rapid release in the lungs or branchia. Carbonic anhydrase makes for the formation of acid urine in the kidney, hydrochloric acid in the gastric mucosa, bicarbonates of pancreatic juice in the pancreas, and eggshells (containing CaCO3) in the oviducts of birds. Carbonic anhydrase is specifically and strongly inhibited by sulfonamides, which contain an aromatic group. Diamox (acetazolamide), Pentazane (methazolamide), and other agents used in the treatment of glaucoma and diseases of the retina and nervous system are examples of especially active carbonic anhydrase inhibitors. Carbonic anhydrase also occurs in the leaves of certain plants.


References in periodicals archive ?
When methanol was used in the mobile organic phase, the sorption of proteins such as insulin, aprotinin, cytochrome c, a-lactalbumin, ribonuclease, peroxidase, albumin, enolase, and L-glutamic dehydrogenase was affected by the sorbent, but the sorption for proteins lysozyme, myoglobin, [beta]-lactoglobulin, elastase, and carbonic anhydrase was unaffected.
Identification of carbonic anhydrase XII as the membrane isozyme expressed in the normal human endometrial epithelium.
et at Immunohistochemical study of colorectal tumors for expression of a novel transmembrane carbonic anhydrase, MN/ CA IX, with potential value as a marker of cell proliferation.
We speculate that, as in our case, carbonic anhydrase inhibition of the endothelium may have been the mechanism of visual impairment.
Carbonic anhydrase IX is a potential tumor marker that shows some promise for earlier detection of RCC.
The proteins, enzymes called carbonic anhydrases, split CO2 into bicarbonate and protons.
Zuker says that, of the genes that are turned on in sour-sensing cells, one stood out: the gene encoding carbonic anhydrase 4, one in an important class of enzymes that helps maintain appropriate levels of C[O.
ATPase inhibition and gastric mucosa carbonic anhydrase (CA) inhibition, and that these enzymes may be functionally coupled (6).
Common causes of renal potassium depletion with metabolic acidosis are diabetic ketoacidosis, carbonic anhydrase inhibitor therapy and renal tubular acidosis, type I if it is distal or type II if it is proximal.
Pepsin has been shown to alter levels of stress-induced proteins (Sep70 and Sep53), as well as depleting levels of E-cadherin and carbonic anhydrase isoenzyme III, (12,13) thus altering the epithelial response to injury.
The results indicate that human-CGRP modulates the activity of both mantle cells and hemocytes and increases carbonic anhydrase activity in vitro.