Carboxyhemoglobin

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carboxyhemoglobin

[kär¦bäk·sē¦hē·mə‚glō·bən]
(biochemistry)
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Carboxyhemoglobin

 

HbCO, a compound formed by the binding of carbon monoxide (CO) to hemoglobin (Hb).

Carboxyhemoglobin solutions are bright red. Their absorption spectrum has maximums at wavelengths of 570 and 539 mμ. Carboxyhemoglobin breaks down to Hb and CO 10, 000 times more slowly than does oxyhemoglobin to Hb and O2. Therefore, when CO is present in inhaled air the oxygen is gradually displaced from the hemoglobin. Even at an atmospheric CO concentration of 0.1 percent, more than half the hemoglobin in the blood is converted to carboxyhemoglobin, interfering with the transfer of O2 from the lungs to the tissues and causing carbonmonoxide poisoning.

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
Comparison of Carboxyhaemoglobin Levels between the Two Groups of Traders.
Identifying these optical fingerprints enables us to extract the concentration of glucose or carboxyhaemoglobin."
Smoking-Induced Elevations in Blood Carboxyhaemoglobin Levels: Effect on Maximal Oxygen Uptake.
When carbon monoxide combines with haemoglobin it forms carboxyhaemoglobin and methaemoglobin which reduces the oxygen-carrying capacity of the blood and can result in hypoxic stress (Alp et al 2006).
Carboxyhaemoglobin is bright red and most pulse oximeters cannot distinguish between it and oxyhaemogtobin, producing falsely high readings.
Sample pre-treatment for CO-oximetric de ermina ion of carboxyhaemoglobin in pu refied blood and cavi y fluid.
Introduction of CO which has over 240 times greater affinity for joining with haemoglobin than oxygen, causes creation of carboxyhaemoglobin (COHb), which renders the transport of [O.sub.2] impossible.
Carbon monoxide exposure results in increased carboxyhaemoglobin, leading to a reduction in placental oxygen delivery, and causes low birth weight and an increase in perinatal death.
One of the problems encountered in measuring oxyhaemoglobin, were the small errors arising from other pigments in the blood, including methaemoglobin, carboxyhaemoglobin and sulfhaemoglobin, as well as reduced haemoglobin.
Further tests carried out on one blood sample, showed the presence of drugs such as Fluoxetine, known as Prozac and other related breakdown products, and Albendazole, an active ingredient in medication prescribed for the treatment of worms, as well as a high level of carboxyhaemoglobin, an indicator of a large amount of carbon monoxide in the blood.
"This dose equivalence is consistent with the reported three to fivefold greater levels of carboxyhaemoglobin (a marker of carbon monoxide exposure) and tar inhaled when smoking a cannabis joint compared with a tobacco cigarette of the same size.
The high concentration of oxygen you breathe in helps the body make oxyhaemoglobin quickly and replace carboxyhaemoglobin.