Carboxyhemoglobin


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carboxyhemoglobin

[kär¦bäk·sē¦hē·mə‚glō·bən]
(biochemistry)

Carboxyhemoglobin

 

HbCO, a compound formed by the binding of carbon monoxide (CO) to hemoglobin (Hb).

Carboxyhemoglobin solutions are bright red. Their absorption spectrum has maximums at wavelengths of 570 and 539 mμ. Carboxyhemoglobin breaks down to Hb and CO 10, 000 times more slowly than does oxyhemoglobin to Hb and O2. Therefore, when CO is present in inhaled air the oxygen is gradually displaced from the hemoglobin. Even at an atmospheric CO concentration of 0.1 percent, more than half the hemoglobin in the blood is converted to carboxyhemoglobin, interfering with the transfer of O2 from the lungs to the tissues and causing carbonmonoxide poisoning.

References in periodicals archive ?
Krill Jr., "Carboxyhemoglobin levels as an index of hemolysis," Pediatrics, vol.
In the present study the average levels of carbon monoxide exhaled by the subjects, although they varied daily, remained within the acceptable range, with an average of 2.69ppm, reaching values for carboxyhemoglobin of 0.43%, no difference being found between the genders nor between smokers and non-smokers (23).
A significant correlation was found between the carboxyhemoglobin levels and neurological findings, cardiological findings and lactate (p<0.05).
Endogenous carboxyhemoglobin concentrations in the assessment of severity in patients with community-acquired pneumonia.
[2] Nonstandard abbreviations: TEE, transesophageal echocardiography; Met-Hb, methemoglobin, G6PD, glucose-6-phosphate dehydrogenase; [O.sub.2]-Hb, oxygenated Hb; deoxy-Hb, deoxyhemoglobin; CO-Hb, carboxyhemoglobin; [MATHEMATICAL EXPRESSION NOT REPRODUCIBLE IN ASCII], [O.sub.2] partial pressure.
The pathology behind this is diverse; it may be caused by anemia, interstitial lung disease, pulmonary vascular disease, increased carboxyhemoglobin, and low oxygen levels in blood [12].
(5) Recent advances in technology have led to the creation of a device (The Rainbow Rad 57) which possess the ability to measure methemoglobin and carboxyhemoglobin in a noninvasive manner allowing a significant improvement in the ability to quickly diagnose and address these medical emergencies.
The most recent statistics for CO poisonings in LA (2010) show there were: 46 LA Poison Control Center (PCC) calls (10 per million population); 15 deaths (3 per million); 22 hospitalizations (5 per million); and 7 positive laboratory reports (carboxyhemoglobin blood volume fraction [greater than or equal to] 12%; 2 per million).
For example, smoking three quick cigarettes before takeoff or smoking 1 to 1.5 packs a day raises your physiological altitude by 2,000 feet because of high baseline levels of carboxyhemoglobin.
Using the chamber and based on Boyle's law, we can increase the percentage of oxygen in the serum 100-fold and reverse the carboxyhemoglobin levels in less than 30 minutes.