Carboxypeptidases


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Related to Carboxypeptidases: Carboxypeptidase B

Carboxypeptidases

 

an enzyme group of the hydrolase class (carboxypeptidase-A, carboxypeptidase-B, and yeast car-boxypeptidase) that catalyze the stepped hydrolysis of polypeptides from the C-end, that is, from the amino acid that contains a free carboxyl group (—COOH). The molecular weight of car-boxypeptidases exceeds 34, 000. Carboxypeptidase-A is most active on aromatic amino acids; carboxypeptidase-B, on lysine or arginene; and yeast carboxypeptidase, on glycine or lysine. In addition, carboxypeptidases have esterase activity (the ability to split ether bonds). Carboxypeptidase-A enters the duodenum from the pancreas where it is produced in the form of inactive procarboxypeptidase-A, which becomes carboxypeptidase-A, primarily under the influence of trypsin.

REFERENCES

Dixon, M., and E. Webb. Fermenty. Moscow, 1966. (Translated from English.)
Mosolov, V. V. Proteoliticheskie fermenty. Moscow, 1971.
References in periodicals archive ?
This indicates that cocoa beans contain carboxypeptidase enzymes with optimal activity at a pH close to 5.8, releasing hydrophobic amino acids whose activity decreases considerably at pH values below 5.0.
Carboxypeptidase A activity was determined by the method of Folk & Schirmer (1963) using as substrate Hippuryl-L-phenylalanine (1 mmol [L.sup.-1]).
Future studies using amino-peptidase, carboxypeptidase, and DPP-IV inhibitors are warranted to determine if peptide degradation is implicated in lowered recoveries and plasma concentrations (14).
CathA is a member of the serine protease family of enzymes, with carboxypeptidase activity at pH 5.5 and deamidase and esterase activity at pH 7.0 [3].
Aspartic protease, [beta]-galactosidase, peroxidase and serine carboxypeptidase were detected in three Ephedra species.
More than 80 zinc enzymes (e.g, alcohol dehydrogenases, aldolases, peptidases, carboxypeptidases, proteases, phosphatases, transphorylases and RNA and DNA polymerases, carbonic anhydrases) have been reported [13-16].
Trichophyton rubrum secreted and membrane-associated carboxypeptidases. Int J Med Microbiol 2008 oct; 298(7-8):669-82.
His research, done in collaboration with freshman and sophomore students, focuses on organic synthesis and enzymology, targeting novel inhibitors for carboxypeptidases. He also collaborates with Professor Gillmore on his photochorome research.
monodon in this study, it could also be safely assumed that other proteases like carboxypeptidases were present in P.
The few enzymes that have been documented include trypsin and carboxypeptidases A and B in Callinectes sapidus (blue crab) (Dendinger, 1987; Dendinger and O'Connor, 1990); [alpha]-amylase in Carcinus maenas (green crab) (Blandamer and Beechy, 1964); and [alpha]-glucosidase in Cancer borealis (jonah crab), Cancer irroratus (rock crab) (Brun and Wojtowicz, 1976), and C.
The pancreas produces the hormones insulin and glucagon (involved in glucose homeostasis) and several digestive enzymes (including amylase, lipase, trypsin, chymotrypsin, and carboxypeptidases).
A number of enzymes, including [Beta]-lactamases, carboxypeptidases, and squalene epoxidase, are under current study to develop inhibitors which may be useful medicinal agents and to gain insights into mechanisms of catalysis.