Results identify miR-29 as a key regulator of cardiac fibrosis
The objectives of the present study were to evaluate the effects of Tanshinone II-A, a bioactive diterpene quinone isolated from Danshen, on cardiac fibrosis
and collagen metabolism in rats with renovascular hypertension.
as a cause of diastolic dysfunction.
Key words: Bosentan, diabetes, fibrotic agents, cardiac fibrosis
, endothelin blockade, tissue growth factor beta, connective tissue growth factor, vascular endothelial growth factor
Pomegranate flower extract also reduced heart muscle signaling of endothelin-1, a vasoconstrictor (blood vessel-narrowing) peptide implicated in cardiac fibrosis
On postmortem examination, chronic renal disease and moderate cardiac fibrosis
and endocardiosis were observed, but these conditions were considered to be age-related.
In humans, the RALES investigators measured a collagen peptide called procollagen type III amino-terminal peptide (PIIINP) as a marker for evidence of cardiac fibrosis
in the study participants [Circulation.
5] The pathologic finding noted is mainly cardiac fibrosis
, with less prominent vacuolization than seen on biopsy specimens examined during or soon after therapy.
Jose Jalife of the University of Michigan Medical School to better understand the contribution of galectin 3 to cardiac fibrosis
in chronic arrhythmias using proprietary inhibitors of galectins, GM-CT-01 and GR-MD-02.
While it has been assumed that fluid and electrolyte imbalances are key contributors to the development of arrhythmias, other factors, including ventricular hypertrophy and cardiac fibrosis
, also may exacerbate the underlying risk," said study co-author James A.
Results: In the SHR, hypertension, myocardium hypertrophy, more cardiac fibrosis
, higher concentrations of serum norepinephrine and myocardium Ang II were observed.
In these studies, the main causative mechanism of fQRS was cardiac fibrosis