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The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.



a pathological condition of the heart muscle caused by the growth therein of connective tissue in place of functional muscular tissue.

Cardiosclerosis as a rule is the result of a chronic or acute heart disease (coronary insufficiency, myocarditis). The condition may be either diffuse or focal. For example, myocardial infarction may result in focal sclerosis. One of the chief and earliest symptoms of cardiosclerosis is shortness of breath (only during physical exertion at the onset of the condition, and later on at rest). As the condition progresses the signs of cardiac insufficiency appear: rapid pulse, edema in the legs, enlargement of the liver, pulmonary congestion, and dyspneic attacks. Irregular heart beat is a frequent manifestation of cardiosclerosis (ex-trasystole, auricular fibrillation). The heart enlarges. The proliferation of connective tissue in the heart valves may result in heart defects.

Treatment is aimed at improving the blood supply to the heart muscle (administration of vasodilators and anticoagulants), correcting cardiac insufficiency (administration of strophanthin, digitalis, diuretics), and eliminating arrhythmia (quinidine, novocainamide).


Lang, G. F. Bolezni sistemy krovoobrashcheniia, 2nd ed. Moscow, 1958.
Miasnikov, A. L. Gipertonicheskaia bolezn’i ateroskleroz. Moscow, 1965.
Wenckebach, K. F. Herz- und Kreislauf-Insuffizienz, 4th ed. Dresden-Leipzig, 1942.
White, P. D. Heart Disease, 3rd ed. New York, 1945.


The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
These results clearly demonstrate a positive effect of cell therapy as ascertained by scintigraphic diagnostics with Tc99 m in patients with CHD and post-infarction cardiosclerosis during 9 months monitoring periods following cell therapy.
We tested the feasibility, safety, and functional effects of the use of enriched [CD.sup.133.+] progenitor cells after intracoronary administration in patients with coronary heart disease and post-infarction cardiosclerosis.
Regrettably, the "cardiosclerosis" of our present political climate is not attuned to analysis and problem solving.
Popov, "Expression of [Ca.sup.2+]-ATPase in sarcoplasmic reticulum in rat cardiomyocytes during experimental postinfarction cardiosclerosis and diabetes mellitus," Bulletin of Experimental Biology and Medicine, vol.
"These latest developments are consistent with the sort of cardiosclerosis that has begun in our country, and it concerns across-the-board life issues," said Cardinal Joseph Tobin of Newark, New Jersey "It is the hardening of the American heart, and the invitation is to harden our hearts further."