From cadherins to catenins
: cytoplasmic protein interactions and regulation of cell adhesion.
Abe, "Synaptic contact dynamics controlled by cadherin and catenins
," Trends in Cell Biology, vol.
 Papkoff J, Rubinfeld B, Schryver B, Polakis P Wnt-1 reg ulates free pools of catenins
and stabilizes APC-catenin complexes.
E-cadherin, the product of the CDH1 gene (16q22.1), is a transmembrane cell adhesion molecule comprising a cytoplasmic domain, which interacts through intracellular catenins
with the actin-based cytoskeleton, and an extracellular domain, which is involved in homotypic cell-to-cell adhesion.
The [alpha], [beta], p, and [gamma] catenins
play important roles in intercellular signal transduction.
Chien, "Integrins regulate VE-cadherin and catenins
: dependence of this regulation on Src, but not on Ras," Proceedings of the National Academy of Sciences of the United States of America, vol.
It forms a complex with E-cadherin as well as other catenins
at the cell membrane forming adherens junctions and mediates the interaction between the cadherin-catenin complex and the actin cytoskeleton.
Classical and non-classical cadherins belong to a superfamily of [Ca.sup.+2]-dependent cell adhesion molecules (Takeichi, 1988, 1991; Pouliot, 1992), and are associated with cytoplasmic proteins named catenins
(Hirano et al., 1987; Ozawa et al., 1989; Nagafuchi and Takeichi, 1989; Stappert and Kemler, 1993; Wheelock et al., 1996; Wahl et al., 1996).
BAKER: Do L cells express the catenins
? If so, are they catenins
found in those junctions, or where you see the cell-cell staining?
For Ecadherin--an adhesion molecule forming complexes with catenins
at epithelial cell-cell adherens junctions that is lost during epithelial-to-mesenchymal transition--positive membrane staining is only seen in the epithelial cells, not the stromal cells.
(13) The E-cadherin complex, essential for the formation of intercellular tight junctions, is composed of the transmembrane E-cadherin protein and [alpha], [beta], [gamma], and p120 catenins
, which anchor the E-cadherin protein to the cytoplasmic actin filaments.