Association between platelet endothelial cellular adhesion molecule
1 (PECAM-1/ CD31) polymorphisms and acute myocardial infarction: a study in patients from Sicily.
Its proprietary drug candidate Cytolin(R) is a monoclonal antibody that binds to CD11a, a cellular antigen that is a component of the cellular adhesion molecule
37,38] The pattern of integrins, a type of cellular adhesion molecule
, expressed by basal cell carcinoma was similar to patterns expressed by the more aggressive malignant melanoma.
3], a cellular adhesion molecule
that's also a growth factor for endothelial cells.
The mechanism by which NO inhibits the expression of cellular adhesion molecule
is via inhibiting the activation of the pro-inflammatory transcription factor, NF-[kappa]B (31,103-105).
The Company's proprietary drug candidate Cytolin(R) is a monoclonal antibody that binds to CD11a, a cellular antigen that is a component of the cellular adhesion molecule
The above mentioned process is in part mediated by cellular adhesion molecules
(CAMs), which attach to the endothelial cell membrane in response to activation by various inflammatory cytokines, like interleukin-1, tumor necrosis factor, and interferon2.
It is well-known that cellular adhesion molecules
have effects on tumor cell invasion and metastasis.
leprae, lesional infiltration by activated T cells, enhanced local expression of inflammatory cytokines such as TNF-a and cellular adhesion molecules
, increased local macrophage activation and increases in levels of pro-inflammatory circulating cytokines in the blood.
5) These contradictory results encouraged us to perform a study to determine the expression of select proto-oncogenes and cellular adhesion molecules
, with a view to defining a marker that helped identify a biologically aggressive neoplasm.
The outcomes were FMD and markers of endothelial dysfunction, including cellular adhesion molecules
, inhibitors and promoters of fibrinolysis, adiponectin, glucose, insulin, C-reactive protein (CRP), lipids, and apolipoprotein B.
Several circulating inflammation factors such as cellular adhesion molecules
and cytokines are associated with cardiovascular disease (8,12,13).