The extracellular domains of the CEACAM group function as homophilic and heterophilic cellular adhesion molecules
or receptors [32-34].
Cellular adhesion molecules
like iutracellular adhesion molecule (ICAM) and Vascular cell adhesion molecules-1 (VCAM-1) can be considered potential markers of vulnerability because such molecules are activated by inflammatory cytokines and chemokines and then released by the endothelium.
It is well-known that cellular adhesion molecules
have effects on tumor cell invasion and metastasis.
leprae, lesional infiltration by activated T cells, enhanced local expression of inflammatory cytokines such as TNF-a and cellular adhesion molecules
, increased local macrophage activation and increases in levels of pro-inflammatory circulating cytokines in the blood.
If future studies confirm our results, cellular adhesion molecules
may be potential targets to prevent restenosis in clinical practice.
(5) These contradictory results encouraged us to perform a study to determine the expression of select proto-oncogenes and cellular adhesion molecules
, with a view to defining a marker that helped identify a biologically aggressive neoplasm.
The outcomes were FMD and markers of endothelial dysfunction, including cellular adhesion molecules
, inhibitors and promoters of fibrinolysis, adiponectin, glucose, insulin, C-reactive protein (CRP), lipids, and apolipoprotein B.
Strategies to inhibit cellular adhesion molecules
. In: Paul, L.C., Issekutz, T.B.
The recruitment of these inflammatory cells and their transendothelial migration is mediated by the cellular adhesion molecules
(CAMs), which are expressed by endothelial cells and circulating leukocytes (monocytes and linfocytes) in response to different inflammatory stimuli (Davies et al., 1993).
Several circulating inflammation factors such as cellular adhesion molecules
and cytokines are associated with cardiovascular disease (8,12,13).
Host defenses to extravascular infections usually elicit proinflammatory cytokines and stimulate increased expression of cellular adhesion molecules
, enhancing leukocyte adhesion.
The new research, she says, "has the implication that other cellular adhesion molecules
may well be major receptors for other, much more pathogenic viruses.