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A discrete nodular lesion of inflammatory tissue in which granulation is significant.



a focal growth of inflammatory origin in the cells of young connective tissue in the form of a small node.

Granuloma develops in connection with various (most often infectious) processes (tuberculosis, syphilis, leprosy, brucellosis, tularemia, actinomycosis), with collagenic diseases (such as rheumatism), and at the sites of entry of foreign bodies. Certain granulomas have more specific names, such as the tubercle in tuberculosis and the gumma in syphilis.

References in periodicals archive ?
Intralesional corticosteroid injection for central giant cell granuloma.
Peripheral and central giant cell granulomas of the jaws.
Long-term clinical and radiological outcomes of surgical management of central giant cell granuloma of the maxilla.
Regression of central giant cell granuloma by a combination of imatinib and interferon: a case report.
Central giant cell granuloma occurs more fre-quently in the mandible than in the maxilla, generally anterior to the first molar and often crosses the mid-line.
The lesion may present no signs or symptoms and may be discovered accidentally, but sometimes, central giant cell granuloma may lead to an expansion of the cortex and perforation, mobility, displacement and root resorption of associated tooth.
Based on these findings a provisional diagnosis of Lateral periodontal cyst was made and under differential diagnosis Central giant cell granuloma, central ossifying fibroma, and radicular cyst were considered.
Central giant cell granuloma in child: A case report Journal of Indian Society for Pedodontics and Preventive Dentistry 2004; 22 (3): 106-108.
Calcitonin treatment for central giant cell granulomas of the mandible: Report of two cases.

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