Our results indicate that the pancreas is divided into two sections: the exocrine and endocrine portion.The exocrine portionis comprised of peripheral gland cells and centroacinar cells
; the endocrine portion consists of islet cells.
After approximately 2.5 weeks, the SOX9 positivity disappeared in most of the GATA4-positive cells; it was thought that the positivity of both the factors was almost completely limited at the postcoital 14th week and this suggested that the cells containing GATA4 were differentiated into the surrounding SOX9-positive centroacinar cells
In the pancreas, ductal and centroacinar cells
were intensely stained for p-mTOR, while islet and acinar cells were p-mTOR negative (Figures 1(c) and 2(b)).
Discovered on gastrointestinal stromal tumor 1 (DOG1) is expressed in pancreatic centroacinar cells
and in solid-pseudopapillary neoplasms-novel evidence for a histogenetic relationship.
Enzymatic secretions from the acinar cell clusters pass through ducts lined with cells (centroacinar cells
) that produce a watery secretion rich in sodium bicarbonate; pancreatic secretions thus have a basic pH to neutralize the highly acidic secretions of the stomach.