Ceruloplasmin


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ceruloplasmin

[sə¦rül·ō¦plaz·mən]
(biochemistry)
The copper-binding serum protein in human blood.

Ceruloplasmin

 

a copper-containing protein of the α2-globulin fraction of blood plasma. It was first discovered and isolated by the Swedish scientists C. Holmberg and C. Laurell in 1948. Its content in human plasma is 0.2–0.3 mg/ml. Ceruloplas-min, which has a molecular weight of 130,000, is bound to 60–99 percent of all the plasma copper ions. Its two molecular forms differ in the number of carbohydrate chains, which consist of galactose, mannose, fucose, N-acetylglucosamine, and sialic-acid residues. Ceruloplasmin has some catalytic activity, oxidizing polyamines, polyphenols, and ascorbic acid (vitamin C). It also takes part in hematopoiesis and the transport of copper to sites where other copper-containing proteins, such as cytochromoe oxidases, are synthesized. In addition, it apparently participates in the regulation of the level of biogenic amines.

There exist genetically determined variants of ceruloplasmin caused by the presence of mutant alleles. The level of ceruloplas-min in blood serum increases nonspecifically during pregnancy, infections, anemias, and malignancies but decreases during the Wilson-Konovalov disease and some other diseases.

N. N. CHERNOV

References in periodicals archive ?
There was an insignificant decrease in mean ceruloplasmin levels in GDM subjects (44.8 [+ or -] 4.09 mg/dl) when compared to the controls (46.1 [+ or -] 3.8 mg/dl) in the second trimester.
The plasma total protein, albumin and ceruloplasmin levels did not show a marked difference (Figure 5a,b,c) in the present study for fish exposed to zinc.
The severely obese group showed a significant increase in ceruloplasmin (U/L) levels when compared to the normal weight group and overweight group (p<0.001), while ceruloplasmin levels in the obese group were significantly increased compared to the normal weight group and overweight group (p<0.001 and p<0.01, respectively).
Although ceruloplasmin binds majority of copper in circulation and also for its transport, its plasma levels cannot be exclusive for copper deficiency, because it is also a reactive protein of acute phase.
Dietary copper, plasma copper, serum ceruloplasmin, TC, LDL-c, HDL-c, and TGL were considered independent variables.
Jeremy, "Does oxidative stress change ceruloplasmin from a protective to a vasculopathic factor?," Atherosclerosis, vol.
Ceruloplasmin concentration was determined by competitive enzyme-linked immunosorbent assay (ELISA) according to the manufacturer's protocol (AssayMax Human Ceruloplasmin ELISA kit EC4001-1, Assaypro LLC, St.
A third group consists of metal-binding proteins that sequester free iron or copper to prevent free radical production (ferritin, transferrin, lactoferrin, and ceruloplasmin).
The diagnostic tests include an increased urinary copper excretion (100 ug/dl), reduced serum ceruloplasmin levels (< 25 mg/dl) and increased hepatic copper concentration (> 200 ug/gm of liver tissue).
into ceruloplasmin. Therefore, in serum, 93% of copper gets tightly
The rest of the work up including hepatitis A, B, C, HIV, HSV, Epstein Barr virus (EBV), alpha1 antitrypsin, ceruloplasmin, iron level, ferritin, and antimitochondrial ab (was unremarkable).