Chagas Disease

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The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Chagas’ Disease

 

(also called American trypanosomiasis), a transmissible parasitic disease of humans and animals caused by trypanosomes. The disease was described in 1909 in Brazil (state of Minas Gerais) by the physician C. Chagas. It occurs in Central and South America, chiefly among the poorest strata of the population, who live in dwellings infested by transmitters of the disease (bloodsucking hemipterous insects, mainly triatomids). Humans and wild and domestic animals suffering from Chagas’ disease are the sources of infection.

Infection occurs when the causative agent, together with insect feces, enters injured skin or the mucous membranes of the eyes, nose, and mouth. The main symptoms are fever and enlargement of the lymph nodes in the acute stage, with involvement of the heart and gastrointestinal tract when the disease becomes chronic. The main methods for controlling Chagas’ disease are improvement of social and living conditions of the people, disinsectization, and destruction of infected animals.

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
Although the precise mechanisms underlying Chagas cardiomyopathy are not completely understood, they involve (a) injury to cardiomyocytes induced by T.
Feitosa et al., "Cell therapy in chagas cardiomyopathy (Chagas arm of the multicenter randomized trial of cell therapy in cardiopathies study): a multicenter randomized trial," Circulation, vol.
The chronic Chagas cardiomyopathy (CCC) is the most severe form of the disease that affects 20 to 30% of the infected individuals.
Chagas cardiomyopathy is a vector-borne parasitic infection caused by the protozoa Trypanosoma cruzi [1].
This review explores the right ventricle anatomic and functional involvement in Chagas cardiomyopathy (CC) while highlighting the contribution of cardiac imaging diagnostic methods in the field.
Background: Diverse cardiovascular signaling routes have been considered critical for Chagas cardiomyopathy caused by the protozoan parasite Trypanosoma cruzi.
Although Chagas cardiomyopathy has some differences from so-called idiopathic dilated cardiomyopathy, (5) aside from direct or indirect evidence of prior Trypanosoma cruzi infection, (6) the two entities are more alike than different.
Recent, highly anticipated results from BENEFIT, a large randomized trial (n = 2,854) showed that benznidazole reduced parasite load but was not helpful in halting cardiac damage at 5 years' follow-up in patients with established Chagas cardiomyopathy (N Engl J Med.
Detection of Trypanosoma cruzi DNA in blood by PCR is associated with Chagas cardiomyopathy and disease severity.
- Chagas Cardiomyopathy Global Clinical Trials Review, H2, 2014