hybridization probe

(redirected from Chemical probe)

hybridization probe

[‚hī·brəd·ə′zā·shən ′prōb]
(cell and molecular biology)
A small molecule of deoxyribonucleic acid or ribonucleic acid that is radioactively labeled and used to identify complementary nucleic acid sequences by hybridization.
References in periodicals archive ?
A series of proprietary small molecule inhibitors were optimized based on the discovery of a chemical probe for WDR5.
The evolution and power of RuiYi's iCAPS technology enables the generation of antibodies to GPCRs with great selectivity, which can be used not only for antibody therapeutic development but also for probing the structure, function, chemical probe discovery, and signaling pathways of GPCRs.
The key to the work is a chemical probe the team created to monitor the activity of many enzymes at once.
Double Wheel Sampler System (DWSS)--The DWSS provides physical transfer of chemical agents from the ground to the chemical probe.
CLEAN-UP: Threadneedle Street in Foleshill which has been at the centre of a chemical probe
The evidence was based on brain scans using a radioactively-tagged chemical probe which latched on to the serotonin transporter proteins that Ecstasy targets.
In 1998, George Ricaurte and Una McCann, of Baltimore, had a glowing chemical probe latch on to serotonin transporter proteins, the thinking being that Ecstasy- damaged brains would glow less .
The evidence was based on brain scans using a radioactively-tagged chemical probe which latches onto the serotonin transporter proteins that ecstasy targets.
Using brain scans and a novel chemical probe developed in CAMH's Research Imaging Centre, CAMH scientists found that the probe had high levels of binding to the dopamine D3 receptor in some people with methamphetamine addiction, compared with those who had no addiction.
To get around that problem, Carroll and Seo used a chemical probe that "traps" sulfenic acid and tags it for recognition by an antibody.
The system will take as input a small blood sample and will rely on the chemical interaction between a 5-FU analogous chemical probe with the sample, which will release in the solution ions that can be easily detected and measured through optical analysis.
Next, they began using hydroxyl radicals as a chemical probe.
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