hybridization probe

(redirected from Chemical probe)

hybridization probe

[‚hī·brəd·ə′zā·shən ′prōb]
(cell and molecular biology)
A small molecule of deoxyribonucleic acid or ribonucleic acid that is radioactively labeled and used to identify complementary nucleic acid sequences by hybridization.
References in periodicals archive ?
The chemical probe is being built and tested in France by Thales Group, the Centre National d'Etudes Spatiales and the Research Institute in Astrophysics and Planetology.
The primary outcome of the trial was barrier function, as measured by a dimethyl sulfoxide (DMSO) chemical probe (Cutis.
RuiYi's scientific founder and iHuman Institute founding director, Ray Stevens, said, 'The evolution and power of RuiYi's iCAPS technology enables the generation of antibodies to GPCRs with great selectivity, which can be used not only for antibody therapeutic development but also for probing the structure, function, chemical probe discovery, and signaling pathways of G protein coupled receptors.
The key to the work is a chemical probe the team created to monitor the activity of many enzymes at once.
Double Wheel Sampler System (DWSS)--The DWSS provides physical transfer of chemical agents from the ground to the chemical probe.
CLEAN-UP: Threadneedle Street in Foleshill which has been at the centre of a chemical probe
The evidence was based on brain scans using a radioactively-tagged chemical probe which latched on to the serotonin transporter proteins that Ecstasy targets.
In 1998, George Ricaurte and Una McCann, of Baltimore, had a glowing chemical probe latch on to serotonin transporter proteins, the thinking being that Ecstasy- damaged brains would glow less .
The evidence was based on brain scans using a radioactively-tagged chemical probe which latches onto the serotonin transporter proteins that ecstasy targets.
At present, the most widely used chemical probe is FURA-2, which changes its fluorescent emission as it binds to free calcium ions.
I will develop, by solid phase peptide synthesis, a chemical probe specifically designed to isolate Nav1.
The technology can be used for engineering of antibodies to GPCRs with great selectivity, which can be applied to antibody therapeutic development, as well as to probing the structure, function, chemical probe discovery and signalling pathways of GPCRs, noted Ray Stevens, founding director of iHuman Institute and scientific founder of RuiYi.
Full browser ?