All have similar molecular architecture: redox active cofactors (chlorin
pigments and quinone molecules) are bound to the proteins.
Investigations have been performed on photobleaching compounds like chlorins
and phthalocyanines in vitro and in vivo (Spikes and Bommer, 1993; Streckyte and Rotomskis, 1993).
e6 dichloride Trisodium salt (Frontier Scientific, USA), was dissolved in PBS with a concentration 1mg/ml and kept frozen before use.
reported a HAuNS-pHLIP-Ce6 antitumor platform, where hollow gold nanospheres (HAuNS) were synthesized to shift localized surface plasmon resonance (LSPR) peak, and then the pH insertion peptide (pHLIP) and Chlorin
e6 (Ce6) were adhered to HAuNS by absorption.
e6 was from Frontier Scientific, USA, and Toluidine blue was from Merck.
An unexpected new property of tetrapyrroles, including tetramethyl coproporphyrin III, tetrabenzoporphine, copper chlorin
e4 ethyl ester, and of carotenoids including zeaxanthin and alpha-cryptoxanthin is their ability to induce mammalian phase 2 proteins that protect cells against oxidants and electrophiles.
Photobleaching of mono-L-aspartyl chlorin
eb (NPe6): a candidate sensitizer for the photodynamic therapy of tumors.
Talaporfin sodium (LS11, Laserphyrin, mono-L-aspartyl chlorin
; Light Sciences Corporation, Snoqualmie, WA, USA) is a chlorophyll and L-aspartic acid derived, pure photo-sensitiser codeveloped by Meiji Seika and Nippon Petrochemicals.
The Derifil CHL preparation was also found to effectively reduce DNA adduction and final tumor incidence in stomach (as well as liver), with a potency compatible with its total chlorin
Sagun, V Knyukshto et al., "Photophysical and photochemical properties of potential porphyrin and chlorin
photosensitizers for PDT," Journal of Photochemistry and Photobiology B Biology, vol.