[USA], Nov 16 (ANI): According to previous researches, anti-malaria drugs known as chloroquines
were repurposed to treat cancer for decades, but until now no one knew exactly what the chloroquines
were targeting when they attack a tumor.
resistance was ruled out for patients if no parasites were detected by microscopy on day 28 or, in case of recurrence, if the chloroquine
blood concentration on the day of recurrence did not exceed >100 ng/mL (6,7).
This research could have significant clinical implications, as Chloroquine
is an existing drug therapy that has been approved by the Food & Drug Administration in the US for many years, potentially offering doctors and researchers a relatively simple way to improve treatment outcomes for cancer patients who receive glutaminase inhibitors in their treatment.
As for quinacrine, about two-thirds of patients who fail hydroxychloroquine or chloroquine
will have a positive response to quinacrine if added (Br J Dermatol.
Later one experimental compound was added per culture plate (Chloroquine
, Compound 1 or Compound 2) at 100 [micro]g/[micro]l.
In Vitro Antimalarial Activity of Piperine, Chloroquine
, Mefloquine, and Artesunate.
The ban on chloroquine
importation and use in Cameroon by 2002 and the consequent removal of chloroquine
drug pressure from the population could be responsible for the return to the sensitive genotype of these markers.
They were treated with chloroquine
as a drug of - choice.
CASE HISTORY: A 21-year-old male was admitted to our emergency department (ED) with an alleged history of ingestion of 10 tablets of Chloroquine
DS (each containing 300mg of chloroquine
base) 4 hours prior to admission in a suicidal attempt.
The actual pathophysiology of chloroquine
retinopathy is still not well understood and while the stages of retinopathy development have been categorised and are well-documented, the actual mechanisms behind them remains a mystery.
Multifocal ERG in chloroquine
retinopathy: regional variance of retinal dysfunction.
This resensitizes the parasites to chloroquine
and appears to block the normal function of the resistance protein, killing the parasite.