Chloroquine


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Related to Chloroquine: hydroxychloroquine, chloroquine phosphate

Chloroquine

 

a compound used in the treatment of malaria and of autoimmune and other diseases. It may be taken orally in the form of tablets or administered as a solution by intramuscular or intravenous injection.

References in periodicals archive ?
[USA], Nov 16 (ANI): According to previous researches, anti-malaria drugs known as chloroquines were repurposed to treat cancer for decades, but until now no one knew exactly what the chloroquines were targeting when they attack a tumor.
Chloroquine resistance was ruled out for patients if no parasites were detected by microscopy on day 28 or, in case of recurrence, if the chloroquine blood concentration on the day of recurrence did not exceed >100 ng/mL (6,7).
This research could have significant clinical implications, as Chloroquine is an existing drug therapy that has been approved by the Food & Drug Administration in the US for many years, potentially offering doctors and researchers a relatively simple way to improve treatment outcomes for cancer patients who receive glutaminase inhibitors in their treatment.
As for quinacrine, about two-thirds of patients who fail hydroxychloroquine or chloroquine will have a positive response to quinacrine if added (Br J Dermatol.
Later one experimental compound was added per culture plate (Chloroquine, Compound 1 or Compound 2) at 100 [micro]g/[micro]l.
In Vitro Antimalarial Activity of Piperine, Chloroquine, Mefloquine, and Artesunate.
The ban on chloroquine importation and use in Cameroon by 2002 and the consequent removal of chloroquine drug pressure from the population could be responsible for the return to the sensitive genotype of these markers.
CASE HISTORY: A 21-year-old male was admitted to our emergency department (ED) with an alleged history of ingestion of 10 tablets of Chloroquine DS (each containing 300mg of chloroquine base) 4 hours prior to admission in a suicidal attempt.
The actual pathophysiology of chloroquine retinopathy is still not well understood and while the stages of retinopathy development have been categorised and are well-documented, the actual mechanisms behind them remains a mystery.
This resensitizes the parasites to chloroquine and appears to block the normal function of the resistance protein, killing the parasite.