chlorzoxazone


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chlorzoxazone

[klȯr′zäks·ə‚zōn]
(pharmacology)
C7H4ClNO2 Crystals with a melting point of 191-191.5°C; soluble in aqueous solutions of alkali hydroxides and in ammonia; used as a skeletal muscle relaxant.
References in periodicals archive ?
CYP2E1 activity was assessed by the formation of 6-hydroxychlorzoxazone from the CYP2E1 probe chlorzoxazone (Wang et al.
Effects of cigarette smoking and carbon monoxide on chlorzoxazone and caffeine metabolism.
Decrease in cytochrome P4502E1 as assessed by the rate of chlorzoxazone hydroxylation in alcoholics during the withdrawal phase.
Until now, the "gold standard" method for CYP2E1 phenotyping has used a probe drug, chlorzoxazone (CZX), administered orally (500 or 250 mg) to fasting individuals and metabolized to 6-hydroxychlorzoxazone (HCZX) by CYP2E1.
Limited Tenders are invited for Expendable medical stores Tab Diclofenac Sodium 50 Mg +Paracetamol 375 Mg + Chlorzoxazone 250 Mg Qty: 15000
At American Therapeutics there have reportedly been three recalls, and the FDA has rescinded the ANDA for chlorzoxazone, stating that it was approved "in error.
Phenacetin, paracetamol, warfarin, tolbutamide, 4-hydroxy-methyltolbutamide, dextromethorphan, dextrorphan, chlorzoxazone, 6-hydroxyl-chiorzoxazone, testosterone, 6[beta]-hydroxyl testosterone, chlorpropamide, chlorpheniramine, [beta]-nicotinamide adenine dinucleotide phosphate (NADP), glucose-6-phosphate, glucose-6-phosphate dehydrogenase and other unspecified reagents were purchased from Sigma Chemical Co.
For example, dextromerhorphan and debrisoquine are known substrates for a particular cytochrome P450 (CYP) enzyme, CYP2D6; trimethadione, chlorzoxazone, and halothane are markers for CYP2E1 activity; morphine is predominantly processed by glucuronidation; and a host of antibiotics are not extensively metabolized but are mostly excreted unchanged by the kidneys (Bertz and Granneman 1997; Dollery 2000; Kurata et al.
Recent studies involving this probe to correlate chlorzoxazone 6-hydroxylase activity (phenotype) with the known polymorphisms of CYP2E1 failed to demonstrate a relation between altered CYP2E1 genotype and the capacity to metabolize chlorzoxazone.
Par received approval to market chlorzoxazone on June 5, and ATI received its approval June 23.
DICLOFENAC 50 mg+ PARACETAMOL 325 mg+ CHLORZOXAZONE 500 mg Tablets, etc.