primary biliary cirrhosis

(redirected from Cholestatic liver disease)
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primary biliary cirrhosis

[¦Prīm·ə·rē ‚bil·ē·er·ē sə′rō·səs]
(medicine)
A slowly progressive disease primarily of middle-aged women, caused by an autoimmune destruction of bile ducts that begins as inflammation in and around larger intrahepatic bile ducts and eventually results in liver cell damage.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Further studies are required in order to elucidate the complex pathogenesis of cholestasis, unlock the mechanism of cholestatic pruritus, and improve the clinical management of both hereditary and acquired cholestatic liver diseases.
The usage of glucocorticoids in CLD treatment (autoimmune and chronic cholestatic liver diseases) may accelerate development of osteoporosis.
Idiopathic adulthood ductopenia: a cause of chronic cholestatic liver disease and biliary cirrhosis.
PBC is a rare, chronic cholestatic liver disease characterized by an immune-mediated destruction of smalland medium-sized intrahepatic bile ducts (Invernizzi, Selmi, & Gershwin, 2010).
Trauner, "Fibrosis in autoimmune and cholestatic liver disease," Best Practice and Research: Clinical Gastroenterology, vol.
Background: Primary biliary cirrhosis (PBC) is a chronic and slowly progressive cholestatic liver disease characterized by destruction of the interlobular bile ducts and a striking female predominance.
EASL clinical practice guideline management of cholestatic liver disease. J Hepatol.
[2,3] These changes are particularly prominent in children with severe cholestatic liver disease such as biliary atresia and the severe intrahepatic causes of CLD.
It is the most common cause of chronic cholestatic liver disease in adults.
Our patient had all of these features in the presence of chronic cholestatic liver disease. She did not have radiological evidence of rickets, her serum calcium and phosphorus levels were normal and she had been receiving treatment with alfacalcidol.
LAP was found to be elevated in papillary adenocarcinoma of bile duct (33) and in cholestatic liver disease (34).