Cholesterol-Lowering Drugs

The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Cholesterol-Lowering Drugs


medicinal substances that lower the level of cholesterol in the blood and are used to treat and prevent atherosclerosis. Three main groups of cholesterol-lowering drugs are distinguished according to their mechanism of action: those that interfere with the absorption of cholesterol from the intestine, those that block the synthesis of cholesterol, and those that intensify the excretion and breakdown of cholesterol.

The first group includes preparations containing plant sterols (for example, betasitosterol), which act on the basis of competitive antagonism to cholesterol, and some substances containing saponins (for example, diosponin), whose interaction with cholesterol forms poorly soluble complexes. The second group includes acetic acid derivatives (for example, phenexan and cetamiphenum), which slow cholesterol synthesis. The best-known preparations of the third group are d-thyroxine and thyroxine-like substances.

Preparations and oils containing unsaturated fatty acids (linetol, corn oil) also lower cholesterol levels. Blood cholesterol sometimes decreases following the use of neurotropic drugs (for example, amytal sodium, phenobarbital, chloral hydrate, chlorpromazine hydrochloride, tropaphenum, and hexamethonium benzosulfenas), vitamins C, B6, B12, E, and PP, some drugs that stimulate the flow of bile from the liver, and male sex hormones.


Miasnikov, A. L. Ateroskleroz. Moscow, 1960.
Mashkovskii, M. D. Lekarstvennye sredstva, 6th ed., part 1. Moscow, 1967.


The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
[USA], Mar 19 (ANI): While probing the side effects of drugs called statins, cholesterol-lowering drugs, cellular chemists rather found their unknown benefits.
"Discovering the mechanism was important because plenty of people are on cholesterol-lowering drugs, especially statins for high cholesterol," said Ko.
These are supposed to be cholesterol-lowering drugs.
HEART disease is better treated with a Mediterranean-style diet than cholesterol-lowering drugs, it has been claimed.
Treatment with the cholesterol-lowering drugs taken by millions of people in the UK is the most likely explanation, they believe.
The researchers compared memory complaints among patients who were taking statin drugs, patients who were taking other types of cholesterol-lowering drugs, and those who were taking no cholesterol-lowering drugs.
The AHA adopted a new approach "that, in its own words meant cholesterol-lowering drugs could be prescribed to an estimated 33 million Americans without cardiovascular disease who have a 7.5 percent or higher risk for a heart attack or stroke within the next 10 years," said Arthur Phillips, a Unite Here research analyst and author of the report.
Researchers reviewed data on 482,543 statin patients, 26,484 users of other cholesterol-lowering drugs, and 482,543 non-users of any cholesterol medications.
Statins, the most powerful cholesterol-lowering drugs, are also very effective at lowering cardiac risk.
Statins, the widely used cholesterol-lowering drugs, may have a role in surgical wound healing, a new analysis suggests.
Cardiovascular agents (medications that are used to treat high blood pressure, heart disease or kidney disease) and cholesterol-lowering drugs were two of the most commonly used classes of prescription therapies among adults 18 to 64 years old and 65 and over in 2007-2010.

Full browser ?