Cholic Acid


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cholic acid

[′kō·lik ′as·əd]
(biochemistry)
C24H40O5 An unconjugated, crystalline bile acid.

Cholic Acid

 

a monocarboxylic steroid acid of the bile acid group. In the bile of animals and man, cholic acid is combined with the amino acids glycine and taurine in the two bile salts—glycocholic acid and taurocholic acid, respectively—that play a part in lipometabolism.

References in periodicals archive ?
Cholic acid is reportedly being considered for approval in a late-stage review by the US FDA and is currently approved in Europe for the treatment of inborn errors in primary bile acid synthesis.
The total cholesterol levels of the liver and feces of rats fed the 1% cholesterol and 0.5% cholic acid diet were significantly higher than those of rats fed the normal diet (Table 2).
Cholic acid and the fluorinated bile acid analogues caused a dose-dependent decrease in the uptake of [[sup.3]H]TC and [[sup.3]H]EbG for NTCP and OATP1B1.
Metal cholates from 95% ethanol: cholic acid was dissolved in 95% ethanol containing one equivalent of sodium hydroxide then, treated with one equivalent of metal salt solution in same solvent.
The supplementation of 0.2% Rutin or 1% cholesterol + 0.5% cholic acid (HCD) or 0.2% RT + 1% cholesterol + 0.5% cholic acid (RT + HCD) to the food did not influence the food intake among all groups.
Oral cholic acid for hereditary defects of primary bile acid synthesis: A safe and effective long-term therapy.
These new solution certified reference materials (CRMs) consist of lithocholic acid, taurocholic acid and native and deuterium-labeled analogs of cholic acid, chenodeoxycholic acid, deoxycholic acid and ursodeoxycholic acid.
Patients with a confirmed HSD3B7 deficiency were treated with informed consent under an Investigational New Drug application (45470) approved by the US Food and Drug Administration for oral cholic acid therapy (10-15 mg/kg per day, n = 10) according to a protocol approved by the Cincinnati Children's Hospital Medical Center Investigational Review Board (#2011-2448).
External bile acid standards, including cholic acid (CA), lithocholic acid (LCA), chenodeoxycholic acid (CDCA), deoxycholic acid (DCA), ursodeoxycholic acid (UDCA), [alpha]-muricholic acid ([alpha]MCA), [beta]-muricholic acid ([beta]MCA), [omega]-muricholic acid ([omega]MCA), glycocholic acid (GCA), glycochenodeoxycholic acid (GCDCA), taurocholic acid (TCA), taurodeoxycholic acid (TDCA), tauro chenodeoxycholic acid (TCDCA), taurolithocholic acid (TLCA), tauro-[alpha]-muricholic acid (T[alpha]MCA), and tauro-[beta]-muricholic acid (T[beta]MCA), were purchased from Sigma-Aldrich.
The Food and Drug Administration approved cholic acid capsules for treatment of children aged 3 weeks and older and adults with bile acid synthesis disorders due to single enzyme defects.
Group E was fed diet 5 (20% canola oil and CCT supplement (Cholesterol, cholic acid, thiouracil comparison of means for lipid profilesofall groups was carried out by analysis of variation (ANOVA) for parametric data and Kruskal Wallis test for non-parametric results.
Savage, Antimicrobial activities of amine- and guanidine functionalized cholic acid derivatives, Antimicrob.