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The correlation between the degree of serum cholinesterase inhibition and the severity of manifestations is pertinent only in the initial stage of acute poisoning and inhibition is greater in repeated exposures, inhibition remains even after recovery from symptoms.
Correlation of succinylcholine duration of action with plasma cholinesterase activity in subjects with the genotypically normal enzyme.
When the inhibitory potential of 1-5 against acetyl cholinesterase and protease were determined, it was revealed that none of these compounds has activity against these enzymes (Table 1).
Cholinesterase inhibitory activity of the test samples was determined by Ellman's microplate assay with modification (Ellman et al.
Hence, profenofos proved to be the most potent inhibitor of cholinesterases (AChE and BuChE) as compared to cabofuran thus appearing to be more toxic for these aquatic animals.
Bradycardia is a contraindication for all cholinesterase inhibitors.
1 percent of the state's 257 tested pesticide handlers red flagged for cholinesterase depressions of at least 20 percent, according to Labor & Industries' 2010 Cholinesterase Monitoring of Pesticide Handlers in Agriculture Final Report.
Donepezil, like other cholinesterase inhibitors, is used to treat early stages of Alzheimer's disease and dementia.
Tacrine (Cognex[TM]) is a centrally acting cholinesterase inhibitor which slows the degradation of acetylcholine in the cerebral cortex.
Cholinesterase inhibitors are among the few drugs used to treat dementia, although their use does not affect the long-term progress of the disease.
The relatively modest benefit of cholinesterase inhibitors--especially given their expense--has raised questions about cost effectiveness.
There is some evidence that certain patients may benefit from higher doses of the cholinesterase inhibitor medications.