chondrocyte

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chondrocyte

[′kän·drō‚sīt]
(histology)
A cartilage cell.
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In the hypertrophic zone (ZH), chondrocytes have a rounded appearance due to cytoplasmic hypertrophy, accompanied by a marked intracellular increase in calcium concentration, and an increase in the synthesis and secretion of X-type collagen, in addition to other proteins Of the MEC (van der Eerden et al.
Receptors for IL-1[beta], TNF-[alpha] and IL-6 have been found in chondrocytes and synoviocytes.
Another was to determine the extent to which collagen rheological properties can be used to predict the printability of collagen bioinks with and without chondrocytes.
Aside from the wide array of evidence showing HTRA1-DDR2MMP-13 activity in osteoarthritis of multiple modalities, the convergence of diverse noxious stimuli upon this axis is further supported in the protective effects exerted in DDR2 hypomorphic strains of mice, which, when subject to the DMM procedure, demonstrated a significant decrease in the progression of osteoarthritis compared to wild type littermates [29], comparable to the ablation of MMP-13, which has the effect of protecting cartilage from degradation in osteoarthritis induced through destabilization of the medial meniscal ligament (DMM-induced osteoarthritis) in murine models, though interestingly enough chances to the chondrocytes themselves and other cells in response to the procedure persisted [17].
Matrix-applied characterized autologous cultured chondrocytes versus microfracture: two-year follow-up of a prospective randomized trial, " The American Journal of Sports Medicine, vol.
The sections were graded using the Mankin grading scheme: [sup][25] (1) Articular cartilage structure, (2) reduced articular cartilage matrix staining, (3) alignment of chondrocytes, and (4) the integrity of the tidal line.
Histological studies of new-borns to one-month old babies evidenced articular cartilage chondrocytes as an immature physis, with disorganized chondrocytes not forming orderly columns.
The trick is to get cartilage-making cells called chondrocytes to grow replacement patches.
2]) inhibits synthesis of proteoglycan structure in cartilage via adenosine triphosphate synthesis and inhibition of glyceraldehyde-3-phosphate dehydrogenase (GAPDH), a glycolytic enzyme in chondrocytes.
In-vitro studies have confirmed that these intraarticular local anesthetic injections, in particular bupivacaine and lidocaine, are cytotoxic to chondrocytes (Braun et al.