balanced translocation

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balanced translocation

[′bal·ənst tranz·lō′kā·shən]
(genetics)
Positional change of one or more chromosome segments in cells or gametes without alteration of the normal diploid or haploid complement of genetic material.
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They have since found out that she had what's known as a chromosomal translocation and had lost a gene essential for growth in the womb.
Karen Soulard, 61, and her daughter Sarah Pearce, 38, have chromosomal translocation, which causes chromosomes to arrange unusually making it difficult for a baby to fully develop.
It is characterized by "t" (11:22) (q24;q12) chromosomal translocation leading to a chimeric transcript EWS-FLI1 formation.
[2] DFSP tumour cells exhibit a chromosomal translocation of genes COL1A9 and PGDF p (t17, 22) which encode to alpha chain of type I collagen and beta chain of platelet derived growth factors.
An overlap between common loci for chromosomal translocation and parental genes involved in intergenic splicing may not be coincidental.
Another key defining feature of all three BL variants is a chromosomal translocation which juxtaposes the c-MYC oncogene on chromosome 8 and one of the three Ig loci, most frequently the Ig heavy chain locus on chromosome 14 [1].
The recent identification of a chromosomal translocation specific to pleuropulmonary synovial sarcoma has increased the recognition of this particular sarcoma subtype.
FISH (fluorescence in situ hybridization) analysis done on sections of the lymph node showed a CCND1-IGH rearrangement, which occurs due to chromosomal translocation t(11;14).
BL is caused by chromosomal translocation and deregulation of the cMYC oncogene; in nonendemic BL regions, it manifests highly aggressive and fast-growing B-cell malignancy.
The chromosomal translocation involving the long arms of chromosomes 14 and 18 has been detected cytogenetically in about 90% of follicular lymphomas and 20-30% of diffuse large cell lymphomas (1).
To determine if LOLA produces a specific signal in cultured cell lines with known chromosomal translocation breakpoints, we used FL cell lines SU-DHL4, SUDHL6, and SU-DHL16 that harbor MBR2, MBR1, and mcr BCL2 breakpoints, respectively (Fig.
The balanced chromosomal translocation carriers have increased risk for pregnancy losses or having children with mental or physical abnormalities because of unbalanced segmental chromosomal losses and gains.

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