Chronic beryllium disease is characterized by a granulomatous reaction in the lung to inhaled beryllium.
Pulmonary granulomas are part of the diagnostic criteria for chronic beryllium disease. (100) However, to obtain a definitive diagnosis, since the histologic changes are not specific, the clinician should consider the possibility of beryllium exposure, obtain an occupational history, and document sensitization to beryllium by performing a beryllium lymphocyte proliferation test on blood or bronchoalveolar lavage fluid.
(244.) Chronic Beryllium Disease
Prevention Program, 64 Fed.
A person driving a delivery truck to the plant could come down with Chronic Beryllium Disease
Department of Energy 2008) and national defense (Business Wire 2005), and advances in the understanding of chronic beryllium disease
(CBD) led us to reconsider the pathogenesis of ABD.
This conclusion is supported by the observation that the rates of chronic beryllium disease
(CBD) and sensitization were constant across all the categories of exposure used by Rosenman et al.
Researchers early on recognized that chronic beryllium disease
(CBD) occurred after both high and low levels of exposure and hypothesized that the disease was immunologically mediated (Sterner and Eisenbud 1951).
The pathobiology of chronic beryllium disease
(CBD) involves the major histocompatibility complex class II human leukocyte antigen (HLA).
Chronic beryllium disease
is an occupational lung disease that begins as a cell-mediated immune response to beryllium.
Some workers who were exposed to beryllium developed chronic beryllium disease
, a disease of the lungs.
Simply reducing current exposure limits may not reduce the number of workers stricken with chronic beryllium disease
(CBD), which results in death in about 30% of sufferers.
The goal of this proposed research initiative is to encourage and support studies that will advance our understanding of the mechanisms of chronic beryllium disease