chymosin

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chymosin

[′kī·mə·sən]
(biochemistry)
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Astragalus polysaccharides inhibited diabetic cardiomyopathy in hamsters depending on supression of heart chymase activation.
2000) Delayed expulsion of the nematode Trichinella spiralis in mice lacking the mucosal mast cell-specific granule chymase, mouse mast cell protease-1.
When the researchers studied blood serum samples from patients with dengue infection, they found that the levels of a protein produced by mast cells, chymase, were significantly higher in the patients who developed dengue hemorrhagic fever compared to those who recovered after dengue fever.
The measurements of serum specific IgE directed to the [beta]-lactams, serum chymase and tryptase levels were not performed (due to a lack of laboratory support).
In spite of the fact that ACE activity in the serum was not significantly affected, yet the observed rise in MDA level in the serum may still have been due, at least in part, to elevation of AT-II through an ACE-independent pathway involving chymase enzyme (Balcells et ah 1997).
They are the chymase, chymotrypsin, angiotensin generating enzyme and cathepsin D pathways.
DRUGS PENDING APPROVAL Drug Indication prasugrel acute coronary syndrome (with Lilly) DRUGS IN PHASE IIB AND BEYOND Drug Indication cs-011 diabetes (rivoglitazone) cs-8635 cardiovascular disease du-176b atrial fibrillation DRUGS IN PHASE IIB AND BEYOND Drug Indication cs-7017 oncology cs-0777 immunosuppressive db-772d oral factor Xa inhibitor cs-8080 anti-arteriosclerosis sun-13834 chymase inhibitor TOP SELLING DRUGS Drug Indication $ (+/- %) Olmesartan hypertension $2,111 23% Levofloxacin anti-infection $977 2% Pravastatin cholesterol $608 -9% Account for 47% of total pharma sales, up from 45% in 2007.
Some of the mediators are histamine, heparin, leukotrienes, serotonin, chemotactic factors, tryptase, chymase and prostaglandins.
Recent evidence has revealed that skin mast cells and mast cell chymase are important for the formation of granulation tissue and the synthesis of collagen fibers that occur at the edge of the wound in the burn-healing model in mice [9].
Distribution, activation and tryptase/ chymase phenotype of mast cells in the rheumatoid lesion.
Immunocytochemical localization of the granuleassociated protease, chymase, to cytoplasmic vesicles after mast cell stimulation by compound 48/80.
The substrate angiotensininogen is then formed into angiotensin I, which is converted to angiotensin II via the activity of several enzymes, including angiotensin converting enzyme (ACE) and chymase.